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Synthesis and Biological Activity of 3-(2-Oxoalkylidene)-3,4-Dihydro-2H-1,4-Benzoxazines

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Pharmaceutical Chemistry Journal Aims and scope

A simple and convenient method for the synthesis of biologically active 3-(2-oxoalkylidene)-3,4-dihydro-2H-1,4-benzoxazin-2-ones was proposed. The structures of the synthesized compounds were established using NMR and IR spectroscopy and mass spectrometry. It was established that the synthesized compounds possessed antioxidant, antiradical, and strong antihypoxant activity and exhibited low acute toxicity, which allowed the search for new antioxidants and antihypoxants among benzoxazines to continue.

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Authors and Affiliations

  1. Perm Penal Service Institute, Perm, 614012, Russia, Ul. Karpinskogo, 125

    S. S. Zykova

  2. Moscow Institute of Physics and Technology (State University), Moscow, 117303, Russia, Ul. Kerchenskaya, 1-A, Bldg.. 1

    O. G. Karmanova

Authors
  1. S. S. Zykova
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  2. O. G. Karmanova
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Correspondence to S. S. Zykova.

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 6, pp. 20 – 24, June, 2015.

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Zykova, S.S., Karmanova, O.G. Synthesis and Biological Activity of 3-(2-Oxoalkylidene)-3,4-Dihydro-2H-1,4-Benzoxazines. Pharm Chem J 49, 362–366 (2015). https://doi.org/10.1007/s11094-015-1286-9

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  • DOI: https://doi.org/10.1007/s11094-015-1286-9

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