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Efficiency of Combining Free and Polymer-Immobilized Prospidin with Doxorubicin for Treatment of Zajdel Ascites Hepatoma in Rats

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Pharmaceutical Chemistry Journal Aims and scope

The antitumor activity and side effects of the drug combinations prospidin + doxorubicin and prospidin hydrogel + doxorubicin were studied in rats with transplanted Zajdel ascites hepatoma. Test animals were divided into one control group and five test groups depending on the therapy protocol. Control animals were not treated. Test groups received (i) an aqueous solution of prospidin; (ii) prospidin hydrogel; (iii) doxorubicin; (iv) prospidin + doxorubicin; and (v) prospidin hydrogel + doxorubicin. The maximum tolerated doses (MTDs) of the drugs were used in monotherapy; half the MTD, in combination chemotherapy. The antitumor activity was evaluated in terms of lethality, lethality from tumor progression, total cure rate, average life expectancy, and prolonged life expectancy. Side and toxic effects were evaluated using data on the blood cell composition and biochemical parameters. It was established that the antitumor activity of combined aqueous prospidin and doxorubicin did not exceed the activity of doxorubicin monotherapy. Side effects of this combination had the same character as those of doxorubicin and were represented by leuko- and thrombocytopenia and nephropathy. The antitumor effect of combined prospidin hydrogel + doxorubicin with respect to lethality was significantly more pronounced than the effect of each individual component. This combination had a statistically significantly lower toxicity than that of the most toxic component.

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Acknowledgments

The work was supported by the Russian Ministry of Education and Science under State Task Project No. 53/3 – 14 “Targeted drug delivery systems based on liposomal and polymeric carriers.” We thank Prof. V. A. Ivanov (Res. Inst. Cytology, RAS, St. Petersburg) for graciously supplying tumor strains and assisting with the work.

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Authors and Affiliations

  1. N. P. Ogarev Mordovia State University, 68 Bol’shevistskaya St., Saransk, Mordovia, 430005, Russia

    N. A. Pyataev, A. V. Kokorev, O. V. Minaeva & N. N. Zyrnyaeva

  2. A. I. Evdokinov Moscow State University of Medicine and Dentistry, Moscow, 127473, Russia

    K. G. Gurevich & A. V. Zaborovskii

  3. TNK Biotechnology Company, 7 Zubovskaya St., Moscow, 119815, Russia

    A. A. Kladiev

  4. Research Institute for Physical Chemical Problems, Belarusian State University, 14 Leningradskaya St., Minsk, 220030, Belarus

    P. P. Bychkovskii & M. Yu. Revtovich

Authors
  1. N. A. Pyataev
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  2. K. G. Gurevich
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  3. A. V. Zaborovskii
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  4. A. V. Kokorev
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  5. O. V. Minaeva
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  6. N. N. Zyrnyaeva
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  7. A. A. Kladiev
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  8. P. P. Bychkovskii
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  9. M. Yu. Revtovich
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Corresponding author

Correspondence to N. A. Pyataev.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 11, pp. 18 – 22, November, 2014.

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Pyataev, N.A., Gurevich, K.G., Zaborovskii, A.V. et al. Efficiency of Combining Free and Polymer-Immobilized Prospidin with Doxorubicin for Treatment of Zajdel Ascites Hepatoma in Rats. Pharm Chem J 48, 714–717 (2015). https://doi.org/10.1007/s11094-015-1179-y

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  • DOI: https://doi.org/10.1007/s11094-015-1179-y

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