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The Role of Neuromodulation and Potential Mechanism in Regulating Heterotopic Ossification

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Abstract

Heterotopic ossification (HO) is a pathological process characterized by the aberrant formation of bone in muscles and soft tissues. It is commonly triggered by traumatic brain injury, spinal cord injury, and burns. Despite a wide range of evidence underscoring the significance of neurogenic signals in proper bone remodeling, a clear understanding of HO induced by nerve injury remains rudimentary. Recent studies suggest that injury to the nervous system can activate various signaling pathways, such as TGF-β, leading to neurogenic HO through the release of neurotrophins. These pathophysiological changes lay a robust groundwork for the prevention and treatment of HO. In this review, we collected evidence to elucidate the mechanisms underlying the pathogenesis of HO related to nerve injury, aiming to enhance our understanding of how neurological repair processes can culminate in HO.

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Acknowledgements

Draft of Fig. 1 was created with BioRender.com.

Funding

This work was supported by the National Natural Science Foundation of China (Nos. 82102600 and 82272485).

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Authors and Affiliations

  1. Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China

    Dengju Li, Yunfeng Li, Yaqi Wang, Senbo An & Shui Sun

  2. Shandong First Medical University, Jinan, Shandong, China

    Dengju Li, Senbo An & Shui Sun

  3. Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China

    Changxing Liu, Haojue Wang & Shui Sun

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  1. Dengju Li
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DL mainly contributed to the topic determination, literature selection, and draft written, CL, HW, YL and YW screened detailed information from the literature and helped in the manuscript discussion. SS and SA approved the direction of the topic, revised the manuscript, and supervised the work.

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Correspondence to Senbo An or Shui Sun.

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Li, D., Liu, C., Wang, H. et al. The Role of Neuromodulation and Potential Mechanism in Regulating Heterotopic Ossification. Neurochem Res (2024). https://doi.org/10.1007/s11064-024-04118-8

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