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Stellate Ganglion Block Improves Postoperative Cognitive Dysfunction in aged rats by SIRT1-mediated White Matter Lesion Repair

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Abstract

Postoperative cognitive dysfunction (POCD) is a common complication of the central nervous system after surgery, especially in elderly patients. Many factors can influence POCD, one of which is white matter lesion. Nowadays, stellate ganglion block (SGB) is considered as an effective intervention for postoperative cognitive dysfunction and SIRT1 may play a role in that, but the exact mechanism remains unclear. Therefore, the underlying mechanisms that SGB improves postoperative cognitive dysfunction through SIRT1 in aged rats and its association with white matter lesion are yet to be elucidated. The role of SIRT1 in the process that stellate ganglion block improves the cognitive impairment, and its association with white matter lesion was investigated using splenectomy-induced POCD model. To investigate this result further, we performed transection of the cervical sympathetic trunk on the basis of POCD model, and the role of SIRT1 was then verified again by intraperitoneal injection of EX527 (5 mg/kg) five min before surgery. Data show that SGB treatment has neuroprotective effects in POCD rats. SGB treatment can ameliorate cognitive impairment, neuroinflammation and neuronal apoptosis in white matter. Moreover, SGB treatment enhanced the expression of SIRT1 in the hippocampus and white matter, decreased NF-κB activity in the hippocampus and white matter. It also increased the levels of inflammatory factor in serum and white matter, primarily at the level of anti-inflammatory factor. These findings indicated that SIRT1-mediate white matter repair could be a new therapeutic target for neurodegenerative illnesses.

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Data Availability

All relevant data are available in the main text or from the authors.

Abbreviations

DMSO :

Dimethyl sulfoxide

ELISA :

Enzyme-linked immunosorbent assay

EMSA :

Electromobility shift assays

IgG-HRP :

Immunoglobulin G-horseradish peroxidase

IL-6 :

Interleukin-6

IL-10 :

Interleukin-10

MRI :

Magnetic resonance imaging

MWM :

Morris water maze test

NF-κB :

Nuclear factor- kappa B

POCD :

Postoperative cognitive dysfunction

PMSF :

phenylmethylsulfonyl fluoride

PVDF :

Polyvinylidene difluoride

RIPA :

radio-immunoprecipitation assay

SD rats :

Sprague-Dawley rats

SGB :

Stellate ganglion block

SIRT1 :

Silent information regulator 1

TNF-α :

Tumor necrosis factor-alpha

WMH :

White matter hyperintensity

WML :

White matter lesion

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Funding

This work was supported by the Science and Technology Research Project of Education Department of Jiangxi Province (No.GJJ200111).

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Authors and Affiliations

  1. Department of Anesthesiology, Second Affiliated Hospital of Nanchang University, 330006, Nanchang, China

    Jun Zhang, Yang Liu, Hejian Li & Qin Liu

  2. Jiangxi Province key of Laboratory of Anesthesiology, 330006, Nanchang, China

    Yanhui Hu, Shuchun Yu & Yong Chen

Authors
  1. Jun Zhang
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  2. Yang Liu
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  3. Hejian Li
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  4. Yanhui Hu
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  5. Shuchun Yu
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  6. Qin Liu
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  7. Yong Chen
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Contributions

Study conception and design and animal study: Jun Zhang, Yang Liu, Hejian Li; data acquisition and analysis: Qin Liu, Yanhui Hu, Shuchun Yu; manuscript draft: Jun Zhang; manuscript revision: Yong Chen. All authors read and agreed to the final manuscript of the manuscript.

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Correspondence to Yong Chen.

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Our study was approved by the Animal Ethics Committee of Nanchang University.

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Zhang, J., Liu, Y., Li, H. et al. Stellate Ganglion Block Improves Postoperative Cognitive Dysfunction in aged rats by SIRT1-mediated White Matter Lesion Repair. Neurochem Res 47, 3838–3853 (2022). https://doi.org/10.1007/s11064-022-03800-z

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