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Effects of Injections of Nanostructured Titanium Dioxide into the Rat Medullary Nuclei Involved in Cardiovascular Control

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Neurophysiology Aims and scope

Effects of injections of titanium dioxide nanoparticles into the medullary nuclei involved in cardiovascular control (nuclei reticularis paramedianus, reticularis lateralis, and ambiguus) on the blood pressure and heart rate were examined in rats. The nanoparticles (TiO2, PlasmaChem GmbH, D-12489 Berlin, Germany) were used in the form of a nanopowder (mixture of rutile and anatase). The average particle size measured using a scanning electron microscope was 21 ± 5 nm, the specific surface area of the particles was 50 ± 10 m2/g, the purity exceeded 99.5%, the Al2O3 content was below 0.3 mass %, and the SiO2 content did not exceed 0.2%. The nanoparticles were dispersed in Krebs solution (pH 7.4) using ultrasonic cavitation processing for 2 min at 37 kHz. The zeta potential of TiO2 suspension was – 7.93 mV. To provide the aggregate stability of aqueous suspensions of TiO2 nanoparticles, the latter were mechanically stirred. Injections of nanosized TiO2 in the mentioned medullary nuclei induced noticeable changes in the blood pressure, which depended on the concentration and the site (nucleus) of injection. Changes in the heart rate were insignificant in all cases.

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Authors and Affiliations

  1. Taras Shevchenko National University, Kyiv, Ukraine

    A. M. Naumenko, O. V. Tsymbalyuk & T. L. Davydovska

  2. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine

    O. V. Dmytrenko, L. M. Shapoval & V. F. Sagach

Authors
  1. A. M. Naumenko
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  2. O. V. Dmytrenko
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  3. L. M. Shapoval
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  4. O. V. Tsymbalyuk
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  5. V. F. Sagach
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  6. T. L. Davydovska
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Correspondence to A. M. Naumenko.

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Naumenko, A.M., Dmytrenko, O.V., Shapoval, L.M. et al. Effects of Injections of Nanostructured Titanium Dioxide into the Rat Medullary Nuclei Involved in Cardiovascular Control. Neurophysiology 50, 409–414 (2018). https://doi.org/10.1007/s11062-019-09772-1

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  • DOI: https://doi.org/10.1007/s11062-019-09772-1

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