Currents through large-conductance cation channels (LCC channels) in the nuclear membrane of cerebellar Purkinje neurons and hippocampal pyramidal neurons of the CA1 area were recorded using the patch-clamp technique. Later on, LCC channels were also found in the nuclear membrane of cardiomyocytes and other cells. In our study, we tried to find blockers of LCC channels, which is important for determining the physiological functions of these channels. It was found that a few N-cholinoblockers, in particular dithylinum and atracurium, are capable of blocking the above channels. Agonists of N-cholinoreceptors (acetylcholine and carbacholine) do not affect the activity of these channels.
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O. A. Kotyk, A. B. Kotlyarova, A. O. Polishchuk, and S. M. Marchenko, “Ion currents through single channels in the nuclear membrane of rat cardiomyocytes,” Fiziol. Zh., 62, No. 6, 3-8 (2016).
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Kotyk, O.A., Kotlyarova, A.B., Pavlova, N.I. et al. Effects of Blockers of Large-Conductance Cation Channels of the Nuclear Membrane. Neurophysiology 49, 151–153 (2017). https://doi.org/10.1007/s11062-017-9644-8
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DOI: https://doi.org/10.1007/s11062-017-9644-8