In experiments on cats with injury of the cortico- and rubro-spinal pathways, we studied the dynamics of recovery of operant (instrumental) food-procuring reactions at different durations of presurgery learning of animals. Operant manipulatory food-procuring movements were realized under conditions of horizontal and vertical tests, which required training for and support of a strictly defined pose in the course of performance of such movements and determined a specific pattern and stability of the coordinated motor phenomenon. The severity of abnormalities of operant food-procuring activity after transection of the lateral funiculus of the spinal cord at the level of С5-С6 and the time interval necessary for compensation of disorders of the developed manipulatory reaction depended significantly on the duration of presurgery motor learning and decreased considerably with increase in this duration. Such increase determined transformation of the pattern of postural rearrangement, which demonstrated no dependence on the amplitude and trajectory of the forthcoming operant phasic movements and was observed under conditions of both horizontal and vertical motor tests. Our results indicate that the main factor providing successful compensation of disorders of the developed operant habit in cats after injury of the cortico- and rubro-spinal pathways is active involvement of the tecto-and reticulo-spinal systems in the process of formation of the reflex. This can be due to an increase in the duration and intensity of presurgery learning of animals.
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E. I. Miklyaeva, E. I. Varlinskaya, M. E. Ioffe, et al., “Differences in the recovery rate of a learned forelimb movement after ablation of the motor cortex in right and left hemisphere in white rats,” Behav. Brain Res., 56, No. 2, 145-154 (1993).
W. Werner, “Neurons in the primate superior colliculus are active before and during arm movements to visual targets,” Eur. J. Neurosci., 5, No. 4, 335-340 (1993).
Yu. V. Vasil’yeva, E. I. Varlinskaya, and E. S. Petrov, “Peculiarities of restoration of a key habit in albino rats depending on injury of the neocortex and initial motor preference,” Pavlov Zh. Vyssh. Nerv. Deyat., 45, No. 6, 362-369 (1995).
B. Alstermark, A. Lundberg, L. G. Pettersson, et al., “Motor recovery after serial spinal cord lesions of defined descending pathways in cat,” Neurosci. Res., 5, No. 1, 68-73 (1987).
J. H. Martin and C. Ghez, “Red nucleus and motor cortex: parallel motor systems for the initiation and control of skilled movement,” Behav. Brain Res., 28, Nos. 1/2, 217-223 (1988).
P. G. Kostyk, Structure and Function of Descending Systems of the Spinal Cord [in Russian], Nauka, Leningrad (1973).
I. B. Kozlovskaya, Afferent Control of Voluntary Movements [in Russian], Nauka, Moscow (1976).
M. E. Ioffe, Mechanisms of Motor Learning [in Russian], Nauka, Moscow (1991).
V. V. Fanardzhyan, O. V. Gevorkyan, R. K. Mallina, et al. “Dynamics of changes of instrumental reflexes in rats after transection of cortico-spinal tract and removal of the sensorimotor cortex,” Sechenov Ross. Fiziol Zh. , 87, No. 2, 145-154 (2001).
B. Alstermark, A. Lundberg, U. Norrsel, and E. Sybirska, “Integration in descending motor pathways controlling the forelimb in the cat,” Exp. Brain Res., 42, Nos. 3/4, 299-318 (1981).
J. Bureš, O. Burešova, and J. Hewstone, Techniques and Basic Experiments for Studying the Brain and Behavior [Russian translation], A. S. Batuec (ed.), Vysshaya Shkola, Moscow (1991).
Y. Gahery, M. Ioffe, J. Massion, and A. Polit, “The postural support of movement in cat and dog,” Acta Neurobiol. Exp., 40, No. 4, 741-756 (1980).
H. G. J. M. Kuypers, “The descending pathways to the spinal cord: their anatomy and function,” Prog. Brain Res., 11, 178-202 (1964).
C. D. Marsden, “The mysterious motor functions of basal ganglia: The Robert Wartenberg lecture,” Neurology, 32, No. 5, 513-539 (1982).
I. Q. Whishaw, J. A. Tomie, and R. L. Ladowsky, “Red nucleus lesions do not affect preference of use, but exacerbate the effect of motor cortex lesions on grasping in the rat,” Behav. Brain Res., 40, No. 2, 131-144 (1990).
M. Kimura, T. Aosaki, Y. Hu, et al., “Activity of primate putamen neurons is selective to the mode of voluntary movements: visually guided, self-initiated or memoryguided,” Exp. Brain Res., 89, No. 3, 473-477 (1992).
I. H. Jenkins, D. J. Brooks, P. D. Nixon, et al., “Motor sequence learning: a study with positron emission tomography,” J. Neurosci., 14, No. 6, 3775-3790 (1994).
V. M. Moroz, N. V. Bratus’, O. V. Vlasenko, et al., “Organization of instrumental food-procuring movements in rats,” Pavlov Zh. Vyssh. Nerv. Deyat., 49, No. 2, 301-312 (1999).
G. E. Alexander and M. D. Crutcher, “Functional architecture of basal ganglia circuits: neural substrates of parallel proсessing,” Trends Neurosci., 13, No. 7, 266-272 (1990).
T. W. Gardiner and R. J. Nelson, “Striatal neuronal activity during the initiation and execution of hand movements made in response to visual and vibratory cues,” Exp. Brain Res., 92, No. 1, 12-26 (1992).
D. Jaeger, S. Gilman, and J. W. Aldridge, “Primate basal ganglia activity in a precued reaching task: preparation for movement,” Exp. Brain Res., 95, No. 1, 51-64 (1993).
N. F. Suvorov, K. B. Shapovalova, and S. V. Albertin, “Involvement of the neostriatum in the mechanisms of instrumental behavior,” Pavlov Zh. Vyssh. Nerv. Deyat., 33, No. 2, 256-266 (1983).
N. F. Suvorov, S. V. Albertin, and N. L. Voilokova, “The neostriatum: neurophysiology and behavior,” Sov. Sci. Rev. F. Physiol. Gen. Biol., 2, 597-677 (1988).
S. V. Albertin, “Effect of stimulation of the DA-reactive systems of the striatum on instrumental food reflexes in cats,” in: Striatal System in the Norm and Pathology [in Russian], Nauka, Leningrad (1984), pp.14-20.
S. V. Albertin, “Involvement of the dopaminereactive system of the caudate nucleus in the control of instrumental conditioned reflexes of different complexities,” Sechenov Fiz. Zh., 71, No. 1, 87-94 (1985).
S. Yu. Budilin and V. N. Mats, “Recovery of motor habit after nucleus caudatus lesion in rats with different preference of forelimb,” Pavlov Zh. Vyssh. Nerv. Deyat., 51, No. 1, 123-127 (2001).
E. Lorincz and M. Fabre-Thorpe, “Effect of pairing red nucleus and motor thalamic lesions on reaching toward moving targets in cats,” Behav. Neurosci., 111, No. 5, 892-907 (1997).
A. S. Batuev and O. P. Tairov, Brain and Organization of Movements [in Russian], Nauka, Leningrad (1976).
J. Hore, J. Meyer-Lohmann, and V. B. Brooks, “Basal ganglia cooling disables learned arm movements of monkeys in the absence of visual guidance,” Science, 195, No. 4, 584-586 (1977).
M. Roldan and A. Reinoso-Suarez, “Cerebellar projections to the superior colliculus in the cat,” J. Neurosci., 1, No. 8, 827-834 (1981).
E. Olivier, A. Grantyn, M. Chat, and A. Berthoz, “The control of slow orienting movements by tectoreticulospinal neurons in the cat: behavior, discharge pattern and underlying connections,” Exp. Brain Res., 93, No. 3, 435-450 (1993).
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Albertin, S.V. Effect of Injury of the Cortico- and Rubro-Spinal Pathways on Operant Food-Procuring Reflexes in Cats. Neurophysiology 46, 352–360 (2014). https://doi.org/10.1007/s11062-014-9455-0
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DOI: https://doi.org/10.1007/s11062-014-9455-0