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Different clinical and cytogenetic features of primary skull base meningiomas and non-skull base meningiomas

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Abstract

Purpose

To investigate the different clinical and cytogenetic features of skull base meningiomas (SBMs) and non-SBMs (NSBMs).

Methods

We conducted a retrospective study on a series of 316 patients with primary intracranial meningiomas. The t-test and the Chi-square test were used to analyze the differences between 194 SBMs and 122 NSBMs. The Cox analysis was used to determine prognostic factors for tumor recurrence.

Results

Compared with NSBMs, on average, the age of patients with SBMs was about 2.88 years younger (p = 0.024); the duration of operation of SBMs was 2.73 h longer (p < 0.001); the duration of hospital stays of patients with SBMs was about 6.76 days longer (p < 0.001); the tumor volume was 7.69 cm3 smaller (p = 0.025); the intraoperative blood loss was 147.61ml more (p = 0.039); the total cost of SBMs was 1.39 times more (p < 0.001); the preoperative KPS, postoperative KPS, and follow-up KPS of patients with SBMs were all respectively lower (p < 0.001); Gross total resection was less achieved (p < 0.001). SBMs (average of 20.80 per sample) had a smaller total number of copy number variations (CNVs) than NSBMs (29.98 per sample) (p = 0.009). Extremely large CNVs (> 5 Mb) were more likely to present in NSBMs (p < 0.001). Cox analysis showed that subtotal resection (p = 0.002) and the total number of CNVs (p = 0.015) were independent risk factors for tumor recurrence.

Conclusions

The clinical and cytogenetic features of SBMs were different from NSBMs. Moreover, the degree of resection and the total number of whole-genome CNVs were independent prognostic factors for tumor recurrence.

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Data Availability

The datasets in this study have been publicly deposited. They can be accessed at: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147673 .

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Funding

This work was supported by the Natural Science Foundation of Beijing (Grant No. J180005 and No. 7192056, Dr. Zhen Wu), the National Key R&D Program of China (2022YFE0112500, Dr. Zhen Wu), and the Higher Education Discipline Innovation Project (the 111 Project No. B13003, Dr. Dake Zhang).

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    Authors and Affiliations

    1. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

      Junpeng Ma, Da Li, Yuan Zhang, Lairong Song, Liangpeng Chen, Yujia Chen, Junting Zhang, Zhen Wu & Liang Wang

    2. Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China

      Yaqiang Hong

    3. Key Laboratory of Biomechanics and Mechanobiology, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Ministry of Education, Beihang University, Beijing, China

      Dake Zhang

    4. No.119 South 4th Ring West Road, Fengtai District, Beijing, 100070, China

      Liang Wang

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    Contributions

    All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Junpeng Ma, Da Li, Yaqiang Hong, Yuan Zhang, Lairong Song, Liangpeng Chen, Yujia Chen, Junting Zhang, Zhen Wu, Dake Zhang, Liang Wang. The first draft of the manuscript was written by Junpeng Ma and Da Li, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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    Correspondence to Liang Wang.

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    This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by Institution Review Board of Beijing Tiantan Hospital, Capital Medical University (2018-08-17/KY2018-268-01).

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    Junpeng Ma and Da Li contributed equally to this work.

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    Ma, J., Li, D., Hong, Y. et al. Different clinical and cytogenetic features of primary skull base meningiomas and non-skull base meningiomas. J Neurooncol 163, 447–453 (2023). https://doi.org/10.1007/s11060-023-04351-1

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