Abstract
Purpose
Meningiomas arising from the confluence of the falx and tentorium (CFT) are a rare and challenging subset of meningiomas. Gamma Knife radiosurgery (GKRS) is well-established as a safe and effective management strategy for intracranial meningiomas, but its role in treating CFT meningiomas is not well-described. This paper reports the largest series focused exclusively on the outcomes of GKRS for CFT meningiomas.
Methods
We retrospectively identified 20 CFT meningiomas out of 2031 meningioma patients who underwent GKRS at our institution between 1987 and 2021. Tumor control, overall survival (OS), and complications were recorded and analyzed. The median tumor margin dose was 13 Gy at the 50% isodose line. The median tumor volume treated was 4.4 cc (IQR 3.5–7.7). The median patient age was 58 years (range 33–83), the median MRI surveillance duration was 59 months (IQR 34–92), and the median overall follow-up duration was 92 months (IQR 42–201).
Results
The local tumor control rate (PFS) at 5 and 10-years were 100% (N=10) and 83% (N=4), respectively. Eight patients had stable tumor volumes and 11 patients had regression. One patient with a twice-operated tumor had delayed progression at 7.5 years and was retreated with GKRS. No patient had adverse radiation effects during the period of MRI surveillance. The 5 and 10-year OS were 100% (N=13) and 100% (N=7), respectively.
Conclusions
GKRS is a valuable therapeutic strategy for patients with newly diagnosed CFT meningiomas or progressive residual tumors after surgical resection.
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References
Hong CK, Hong JB, Park H, Moon JH, Chang JH, Lee KS, Park SW (2016) Surgical treatment for falcotentorial meningiomas. Yonsei Med J 57:1022–1028. https://doi.org/10.3349/ymj.2016.57.4.1022
Okami N, Kawamata T, Hori T, Takakura K (2001) Surgical treatment of falcotentorial meningioma. J Clin Neurosci 8(Suppl 1):15–18. https://doi.org/10.1054/jocn.2001.0870
Raco A, Agrillo A, Ruggeri A, Gagliardi FM, Cantore G (2004) Surgical options in the management of falcotentorial meningiomas: report of 13 cases. Surg Neurol 61:157–164. https://doi.org/10.1016/s0090-3019(03)00573-1
Zhao X, Belykh E, Przybylowski CJ, Borba Moreira L, Gandhi S, Tayebi Meybodi A, Cavallo C, Valli D, Wicks RT, Nakaji P (2019) Surgical treatment of falcotentorial meningiomas: a retrospective review of a single-institution experience. J Neurosurg. https://doi.org/10.3171/2019.4.JNS19208
Franco DeMonte MWM, Al-Mefty O (2012) Falcotentorial meningiomas. Al-Mefty’s Meningiomas, 2nd edn. Thieme Medical Publishers, Stuttgart
Agarwal V, McCutcheon BA, Hughes JD, Carlson ML, Glasgow AE, Habermann EB, Nguyen QB, Link MJ, Van Gompel JJ (2017) Trends in management of intracranial meningiomas: analysis of 49,921 cases from modern cohort. World Neurosurg 106:145–151. https://doi.org/10.1016/j.wneu.2017.06.127
Sheehan J, Pikis S, Islim AI, Chen CJ, Bunevicius A, Peker S, Samanci Y, Nabeel AM, Reda WA, Tawadros SR, El-Shehaby AMN, Abdelkarim K, Emad RM, Delabar V, Mathieu D, Lee CC, Yang HC, Liscak R, Hanuska J, Alvarez RM, Patel D, Kondziolka D, Moreno NM, Tripathi M, Speckter H, Albert C, Bowden GN, Benveniste RJ, Lunsford LD, Jenkinson MD (2022) An international multicenter matched cohort analysis of incidental meningioma progression during active surveillance or after stereotactic radiosurgery: the IMPASSE study. Neuro Oncol 24:116–124. https://doi.org/10.1093/neuonc/noab132
Quinones-Hinojosa A, Chang EF, Chaichana KL, McDermott MW (2009) Surgical considerations in the management of falcotentorial meningiomas: advantages of the bilateral occipital transtentorial/transfalcine craniotomy for large tumors. Neurosurgery. https://doi.org/10.1227/01.NEU.0000344642.98597.A7
Quinones-Hinojosa A, Chang EF, McDermott MW (2003) Falcotentorial meningiomas: clinical, neuroimaging, and surgical features in six patients. Neurosurg Focus 14:e11. https://doi.org/10.3171/foc.2003.14.6.11
Flickinger JC, Kondziolka D, Niranjan A, Maitz A, Voynov G, Lunsford LD (2004) Acoustic neuroma radiosurgery with marginal tumor doses of 12 to 13 Gy. Int J Radiat Oncol Biol Phys 60:225–230. https://doi.org/10.1016/j.ijrobp.2004.02.019
Bonnal J, Brotchi J (1978) Surgery of the superior sagittal sinus in parasagittal meningiomas. J Neurosurg 48:935–945. https://doi.org/10.3171/jns.1978.48.6.0935
Giombini S, Solero CL, Lasio G, Morello G (1984) Immediate and late outcome of operations for parasagittal and falx meningiomas. Report of 342 cases. Surg Neurol 21:427–435. https://doi.org/10.1016/0090-3019(84)90446-4
Schmid-Elsaesser R, Steiger HJ, Yousry T, Seelos KC, Reulen HJ (1997) Radical resection of meningiomas and arteriovenous fistulas involving critical dural sinus segments: experience with intraoperative sinus pressure monitoring and elective sinus reconstruction in 10 patients. Neurosurgery. https://doi.org/10.1097/00006123-199711000-00001
Sindou M (2001) Meningiomas invading the sagittal or transverse sinuses, resection with venous reconstruction. J Clin Neurosci 8(Suppl 1):8–11. https://doi.org/10.1054/jocn.2001.0868
Asari S, Maeshiro T, Tomita S, Kawauchi M, Yabuno N, Kinugasa K, Ohmoto T (1995) Meningiomas arising from the falcotentorial junction. Clinical features, neuroimaging studies, and surgical treatment. J Neurosurg 82:726–738. https://doi.org/10.3171/jns.1995.82.5.0726
Konovalov AN, Spallone A, Pitzkhelauri DI (1996) Meningioma of the pineal region: a surgical series of 10 cases. J Neurosurg 85:586–590. https://doi.org/10.3171/jns.1996.85.4.0586
Piatt JH Jr, Campbell GA (1983) Pineal region meningioma: report of two cases and literature review. Neurosurgery 12:369–376. https://doi.org/10.1227/00006123-198304000-00002
Goto T, Ohata K, Morino M, Takami T, Tsuyuguchi N, Nishio A, Hara M (2006) Falcotentorial meningioma: surgical outcome in 14 patients. J Neurosurg 104:47–53. https://doi.org/10.3171/jns.2006.104.1.47
Bowden G, Faramand A, Mallella A, Wei Z, Patel K, Niranjan A, Lunsford LD (2021) Does the timing of radiosurgery after grade 1 meningioma resection affect long-term outcomes? Stereotact Funct Neurosurg 99:506–511. https://doi.org/10.1159/000517427
Park KJ, Kano H, Iyer A, Liu X, Tonetti DA, Lehocky C, Faramand A, Niranjan A, Flickinger JC, Kondziolka D, Lunsford LD (2018) Gamma Knife stereotactic radiosurgery for cavernous sinus meningioma: long-term follow-up in 200 patients. J Neurosurg. https://doi.org/10.3171/2018.2.JNS172361
Kondziolka D, Madhok R, Lunsford LD, Mathieu D, Martin JJ, Niranjan A, Flickinger JC (2009) Stereotactic radiosurgery for convexity meningiomas. J Neurosurg 111:458–463. https://doi.org/10.3171/2008.8.JNS17650
Ha MH, Jang WY, Jung TY, Kim IY, Lim SH, Moon KS, Jung S (2020) Treatment outcome of Gamma Knife radiosurgery for petroclival meningiomas: retrospective analysis of a single institution experience. Brain Tumor Res Treat 8:83–92. https://doi.org/10.14791/btrt.2020.8.e16
Sadik ZHA, Lie ST, Leenstra S, Hanssens PEJ (2018) Volumetric changes and clinical outcome for petroclival meningiomas after primary treatment with Gamma Knife radiosurgery. J Neurosurg 129:1623–1629. https://doi.org/10.3171/2017.7.JNS17380
Kim JW, Kim DG, Se YB, Kim SK, Chung HT, Paek SH, Jung HW (2017) Gamma Knife radiosurgery for petroclival meningioma: long-term outcome and failure pattern. Stereotact Funct Neurosurg 95:209–215. https://doi.org/10.1159/000475763
Harrison G, Kano H, Lunsford LD, Flickinger JC, Kondziolka D (2016) Quantitative tumor volumetric responses after Gamma Knife radiosurgery for meningiomas. J Neurosurg 124:146–154. https://doi.org/10.3171/2014.12.JNS141341
Bassiouni H, Asgari S, Konig HJ, Stolke D (2008) Meningiomas of the falcotentorial junction: selection of the surgical approach according to the tumor type. Surg Neurol. https://doi.org/10.1016/j.surneu.2007.02.029
Samii M, Carvalho GA, Tatagiba M, Matthies C, Vorkapic P (1996) Meningiomas of the tentorial notch: surgical anatomy and management. J Neurosurg 84:375–381. https://doi.org/10.3171/jns.1996.84.3.0375
Ge Y, Liu D, Zhang Z, Li Y, Lin Y, Wang G, Zong Y, Liu E (2019) Gamma Knife radiosurgery for intracranial benign meningiomas: follow-up outcome in 130 patients. Neurosurg Focus 46:E7. https://doi.org/10.3171/2019.3.FOCUS1956
Chang JH, Chang JW, Choi JY, Park YG, Chung SS (2003) Complications after gamma knife radiosurgery for benign meningiomas. J Neurol Neurosurg Psychiatry 74:226–230. https://doi.org/10.1136/jnnp.74.2.226
Champeaux-Depond C, Weller J, Froelich S, Resche-Rigon M (2021) A nationwide population-based study on overall survival after meningioma surgery. Cancer Epidemiol 70:101875. https://doi.org/10.1016/j.canep.2020.101875
Kreil W, Luggin J, Fuchs I, Weigl V, Eustacchio S, Papaefthymiou G (2005) Long term experience of Gamma Knife radiosurgery for benign skull base meningiomas. J Neurol Neurosurg Psychiatry 76:1425–1430. https://doi.org/10.1136/jnnp.2004.049213
Kondziolka D, Patel AD, Kano H, Flickinger JC, Lunsford LD (2016) Long-term outcomes after Gamma Knife radiosurgery for meningiomas. Am J Clin Oncol 39:453–457. https://doi.org/10.1097/COC.0000000000000080
DiBiase SJ, Kwok Y, Yovino S, Arena C, Naqvi S, Temple R, Regine WF, Amin P, Guo C, Chin LS (2004) Factors predicting local tumor control after gamma knife stereotactic radiosurgery for benign intracranial meningiomas. Int J Radiat Oncol Biol Phys 60:1515–1519. https://doi.org/10.1016/j.ijrobp.2004.05.073
Brodbelt AR, Barclay ME, Greenberg D, Williams M, Jenkinson MD, Karabatsou K (2019) The outcome of patients with surgically treated meningioma in England: 1999–2013. A cancer registry data analysis. Br J Neurosurg 33:641–647. https://doi.org/10.1080/02688697.2019.1661965
Ostrom QT, Gittleman H, Liao P, Vecchione-Koval T, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS (2017) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2010–2014. Neuro Oncol 19:v1–v88. https://doi.org/10.1093/neuonc/nox158
Holleczek B, Zampella D, Urbschat S, Sahm F, von Deimling A, Oertel J, Ketter R (2019) Incidence, mortality and outcome of meningiomas: a population-based study from Germany. Cancer Epidemiol 62:101562. https://doi.org/10.1016/j.canep.2019.07.001
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ANM, HA, AN, LDL designed the study. HMA and ZW collected the data. HMA and AM performed data analysis and prepared the figures. HMA, ANM, HA and ZW wrote the main manuscript text. LDL and AN edited the manuscript. LDL and ANM oversaw the study.
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Dr Lunsford is a stockholder in Elekta AB. The other authors have no personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article.
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Abdallah, H.M., Mallela, A.N., Wei, Z. et al. Gamma Knife radiosurgery for meningiomas of the confluence of the falx and tentorium. J Neurooncol 161, 225–233 (2023). https://doi.org/10.1007/s11060-022-04125-1
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DOI: https://doi.org/10.1007/s11060-022-04125-1