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Incidence trends and survival analysis of atypical meningiomas: a population-based study from 2004 to 2018

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Abstract

Purpose

Atypical meningiomas have histologic and clinical features that fall between those for benign and malignant meningiomas. The incidence of atypical meningiomas has not been well studied with respect to changes in the World Health Organization (WHO) classification scheme over time.

Methods

The National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database was queried to obtain data from 2004 to 2018 for patients with all meningiomas, including atypical. Age-adjusted incidence rates were generated and annual percent change (APC) in the incidence rates was calculated with joinpoint regression. Survival was analyzed using the Kaplan–Meier method and Cox proportional hazards models.

Results

A total of 4476 patients diagnosed with meningioma were identified from the SEER 18 registries. The incidence of atypical meningioma increased at an APC of 5.6% [95% confidence interval [CI], 3.4–7.8]; significantly faster than all meningiomas, which rose at an APC of 2.5% (95%CI 1.8–3.1;p = 0.008). For atypical meningiomas, the 1, 3, 5, and 10-year survival rates were 91.9%, 81.3%, 68.8%, and 34.3%, respectively. Male sex, older age (≥ 60 years), and large tumor size (> 5 cm) were independent risk factors for an unfavorable prognosis.

Conclusions

The incidence of atypical meningioma was observed to be increasing relative to all meningiomas. It is important to diligently monitor atypical meningioma incidence and mortality rates over time to see whether observed uptrends persist. Continued effort toward improving outcomes in patients with atypical meningiomas is warranted, especially in light of an apparent rise in incidence.

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Abbreviations

AAPC:

Average annual percent change

APC:

Annual percent change

API:

Asian or Pacific Islander

CI:

Confidence interval

Cm:

Centimeters

HR:

Hazard ratio

ICD-O-3:

International classification of diseases for oncology, 3rd edition

SEER:

Surveillance epidemiology, and end results

US:

United States

WHO:

World Health Organization

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Acknowledgements

The authors thank Paul H. Dressel BFA for preparation of the tables and figures and Carrie Owens MSILS and Debra J. Zimmer for editorial assistance.

Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, 100 High Street, Suite B4, Buffalo, NY, 14203, USA

    Matthew J. Recker, Dheerendra Prasad & Robert J. Plunkett

  2. Department of Neurosurgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA

    Matthew J. Recker, Dheerendra Prasad & Robert J. Plunkett

  3. Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, Buffalo, NY, USA

    Cathleen C. Kuo

  4. Department of Radiation Oncology, Jacobs School of Medicine at the University at Buffalo, Buffalo, NY, USA

    Dheerendra Prasad

  5. Department of Radiation Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA

    Dheerendra Prasad

  6. Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA

    Kristopher Attwood

Authors
  1. Matthew J. Recker
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Contributions

RJP, MJR: contributed to the study conception and design. CCK, MJR, KA: Material preparation, data collection and analysis were performed. CCK, MJR: The first draft of the manuscript was written and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Robert J. Plunkett.

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Conflict of interest

The authors have no competing interests related to this study.

Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Ethical approval

The University at Buffalo Institutional Review Board determined that this study was not research involving human subjects and that their review and approval was not required.

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Recker, M.J., Kuo, C.C., Prasad, D. et al. Incidence trends and survival analysis of atypical meningiomas: a population-based study from 2004 to 2018. J Neurooncol 160, 13–22 (2022). https://doi.org/10.1007/s11060-022-04085-6

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  • DOI: https://doi.org/10.1007/s11060-022-04085-6

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