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Surgical treatment of glioblastoma in the elderly: the impact of complications

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Abstract

The diagnosis of glioblastoma (GBM) often carries a dismal prognosis, with a median survival of 14.6 months. A particular challenge is the diagnosis of GBM in the elderly population (age > 75 years), who have significant comorbidities, present with worse functional status, and are at higher risk with surgical treatments. We sought to evaluate the impact of current GBM treatment, specifically in the elderly population. The authors undertook a retrospective review of all patients aged 75 or older who underwent treatment for GBM from 1997 to 2016. Patient outcomes were evaluated with regards to demographics, surgical variables, postoperative treatment, and complications. A total of 82 patients (mean age 80.5 ± 3.8 years) were seen. Most patients presented with confusion (57.3%) and associated comorbidities, and prior anticoagulation use was common in this age group. Extent of resection (EOR) included no surgery (9.8%), biopsy (22.0%), subtotal resection (40.2%), and gross-total resection (23.2%). Postoperative adjuvant therapy included temozolomide (36.1%), radiation (52.5%), and bevacizumab (11.9%). A mean overall survival of 6.3 ± 1.2 months was observed. There were 34 complications in 23 patients. Improved survival was seen with increased EOR only for patients without postoperative complications. A multivariate Cox proportional hazards model showed that complications (HR = 5.43, 95% CI 1.73, 17.04, p = 0.004) predicted poor outcome. Long-term survivors (> 12 months survival) and short-term survivors had similar median preoperative Karnofsky Performance Scale (KPS) score (80 vs. 80, p = 0.43), but long-term survivors had unchanged postoperative KPS (80 vs. 60, p = 0.02) and no complications (0/9 vs. 23/72, p = 0.04). The benefit of glioblastoma treatment in our series was limited by the postoperative complications and KPS. Presence of a complication served as an independent risk factor for worsened overall survival in this age group. It is likely that decreased patient function limits postoperative adjuvant therapy and predisposes to higher morbidity especially in this age group.

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Acknowledgements

We thank Kristin Kraus, M.Sc., for her editorial assistance.

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Author notes

  1. Michael Karsy, Nam Yoon, and Lillian Boettcher have contributed equally to this work.

Authors and Affiliations

  1. Departments of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, 84132, USA

    Michael Karsy, Nam Yoon, Lillian Boettcher, Randy Jensen, Joel MacDonald & Sarah T. Menacho

  2. Departments of Neuroradiology, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USA

    Lubdha Shah

Authors
  1. Michael Karsy
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  2. Nam Yoon
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  3. Lillian Boettcher
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  4. Randy Jensen
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  6. Joel MacDonald
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  7. Sarah T. Menacho
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Correspondence to Sarah T. Menacho.

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Karsy, M., Yoon, N., Boettcher, L. et al. Surgical treatment of glioblastoma in the elderly: the impact of complications. J Neurooncol 138, 123–132 (2018). https://doi.org/10.1007/s11060-018-2777-9

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  • DOI: https://doi.org/10.1007/s11060-018-2777-9

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