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MicroRNA-211 expression is down-regulated and associated with poor prognosis in human glioma

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Abstract

Accumulating evidence has supported the role of microRNAs in the initiation and development of malignant tumors. MicroRNA-211 (miR-211), which was reported to involve in diverse physiological activities in several cancers, was investigated for its expression in human glioma and adjacent normal brain tissues, as well as its correlation with patient prognosis. Glioma tissues and adjacent normal brain tissues were obtained from 82 patients who underwent surgical resection, and quantitative real-time polymerase chain reaction was performed to assess the expression level of miR-211. Here, we found that miR-211 was significantly decreased in glioma tissues compared with adjacent normal brain tissues (glioma, 3.52 ± 0.14 vs. normal, 4.96 ± 0.17, p < 0.001), and inversely associated with ascending WHO classification (grade III–IV, 3.16 ± 0.21 vs. grade I–II, 4.22 ± 0.26, p < 0.001). Then, the correlation of miR-211 with clinicopathological factors was investigated by Pearson’s Chi square test, indicating that miR-211 might be a potential biomarker to predict the malignant status of glioma. Further, Kaplan–Meier curves with log-rank analysis were carried out to determine the relationship between miR-211 expression level and the overall survival rate of glioma patients. Our data showed that there was a close correlation between down-regulated miR-211 and shorter survival time in 82 patients (p = 0.026). Finally, the multivariate Cox regression analysis indicated that WHO grade (HR = 2.437, 95% CI 1.251–4.966, p = 0.007), KPS (HR = 2.215, 95% CI 1.168–4.259, p = 0.016), and miR-211 expression level (HR = 3.614, 95% CI 2.152–6.748, p < 0.001) were considered as independent risk factors for glioma prognosis. These results suggested that lower miR-211 expression might be a marker for poor prognosis of glioma patients.

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    Authors and Affiliations

    1. Department of Neurosurgery, Dalang Hospital, Dongguan, 523770, Guangdong, China

      Jun Zhang, Jianguang Lv, Qiwei Liao & Wobin Huang

    2. Department of Neurosurgery, The Fourth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 511447, Guangdong, China

      Feng Zhang

    3. Department of Neurosurgery, The First Affiliated Hospital of Xi’an Medical University, Xi’an, 710077, Shaanxi, China

      Hongmin Che

    4. Department of Neurosurgery, People’s Hospital, Dongguan, 523770, Guangdong, China

      Shaopeng Li

    5. Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, 710038, Shaanxi, China

      Yuqian Li

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    1. Jun Zhang
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    2. Jianguang Lv
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    3. Feng Zhang
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    5. Qiwei Liao
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    Correspondence to Shaopeng Li or Yuqian Li.

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    The authors report no conflict of interest.

    Ethical approval

    All procedures performed in the present study were approved by the Research Ethics Committee of Tangdu Hospital of Fourth Military Medical University.

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    Informed consent was obtained from all participants before surgery.

    Additional information

    Jun Zhang, Jianguang Lv and Feng Zhang have contributed equally to this study.

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    Zhang, J., Lv, J., Zhang, F. et al. MicroRNA-211 expression is down-regulated and associated with poor prognosis in human glioma. J Neurooncol 133, 553–559 (2017). https://doi.org/10.1007/s11060-017-2464-2

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    • DOI: https://doi.org/10.1007/s11060-017-2464-2

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