Skip to main content

Advertisement

SpringerLink
Log in

Clinical features and long-term outcomes of pediatric spinal meningiomas

  • Clinical Study
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Pediatric spinal meningiomas are very rare. Most studies on pediatric spinal meningiomas are case reports with literature reviews. This study presented a surgical series of 14 pediatric patients with histologically proven sporadic spinal meningiomas, including 5 WHO grade II tumors. In this series, there were 9 male and 5 female patients with a mean age of 11.1 years. Seven tumors were located in the cervical spine, 5 in the thoracic spine, and 2 in the lumbar spine. Gross total resection (GTR) of the tumor with a well-demarcated dissection plane was achieved in 11 cases, subtotal resection was achieved in 2 cases, and partial resection was performed in 1 case. The symptoms were improved in 10 cases at the last follow-up and the current status of 2 patients worsened and 1 patient had no change compared to the preoperative presentation. One patient died of progressive tumor regrowth after partial resection and adjuvant radiotherapy. The postoperative follow-up magnetic resonance imaging showed tumor recurrence in one of the 11 GTR cases during the mean follow-up period of 72.5 months. Recurrence/regrowth of the residual tumors was observed in both the 2 STR cases. Although pediatric spinal meningiomas have a higher incidence of WHO grade II meningiomas, they are amenable to surgery if it is possible to achieve GTR. A good clinical outcome after GTR can be expected, even for WHO grade II meningiomas. Effect of adjuvant radiochemotherapy for controlling the tumors is still unclear and requires further investigation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Rushing EJ, Olsen C, Mena H, Rueda ME, Lee YS, Keating RF, Packer RJ, Santi M (2005) Central nervous system meningiomas in the first two decades of life: a clinicopathological analysis of 87 patients. J Neurosurg 103:489–495

    PubMed  Google Scholar 

  2. Solero CL, Fornari M, Giombini S, Lasio G, Oliveri G, Cimino C, Pluchino F (1989) Spinal meningiomas: review of 174 operated cases. Neurosurgery 25:153–169

    Article  CAS  PubMed  Google Scholar 

  3. Thuijs NB, Uitdehaag BM, Van Ouwerkerk WJ, van der Valk P, Vandertop WP, Peerdeman SM (2012) Pediatric meningiomas in The Netherlands 1974–2010: a descriptive epidemiological case study. Childs Nerv Syst 28:1009–1015

    Article  PubMed  PubMed Central  Google Scholar 

  4. Vural M, Arslantaş A, Ciftçi E, Artan S, Atasoy MA (2007) An unusual case of cervical clear-cell meningioma in pediatric age. Childs Nerv Syst 23:225–229

    Article  PubMed  Google Scholar 

  5. Wilson PE, Oleszek JL, Clayton GH (2007) Pediatric spinal cord tumors and masses. J Spinal Cord Med 30:S15–S20

    Article  PubMed  PubMed Central  Google Scholar 

  6. Vaneckova M, Seidl Z, Kemlink D, Zamecnik J, Burgetova A (2008) Cervical meningioma in childhood. A case report. Neuroradiol J 21:383–387

    Article  CAS  PubMed  Google Scholar 

  7. Greene S, Nair N, Ojemann JG, Ellenbogen RG, Avellino AM (2008) Meningiomas in children. Pediatr Neurosurg 44:9–13

    Article  PubMed  Google Scholar 

  8. Mehta N, Bhagwati S, Parulekar G (2009) Meningiomas in children: a study of 18 cases. J Pediatr Neurosci 4:61–65

    Article  PubMed  PubMed Central  Google Scholar 

  9. Santos MV, Furlanetti L, Valera ET, Brassesco MS, Tone LG, de Oliveira RS (2012) Pediatric meningiomas: a single-center experience with 15 consecutive cases and review of the literature. Childs Nerv Syst 28:1887–1896

    Article  PubMed  Google Scholar 

  10. Wang XQ, Zeng XW, Zhang BY, Dou YF, Wu JS, Jiang CC, Zhong P, Chen H (2012) Spinal meningioma in childhood: clinical features and treatment. Childs Nerv Syst 28:129–136

    Article  PubMed  Google Scholar 

  11. Ben Nsir A, Boubaker A, Jemel H (2014) Cervico-occipital meningioma in a 5-year-old child: a case report. Turk Neurosurg 24:131–134

    PubMed  Google Scholar 

  12. Fortuna A, Nolletti A, Nardi P, Caruso R (1981) Spinal neurinomas and meningiomas in children. Acta Neurochir (Wien) 55:329–341

    Article  CAS  Google Scholar 

  13. Amirjamshidi A, Mehrazin M, Abbassion K (2000) Meningiomas of the central nervous system occurring below the age of 17: report of 24 cases not associated with neurofibromatosis and review of literature. Child Nerv Syst 16:406–416

    Article  CAS  Google Scholar 

  14. Turgut M, Ozcan OE, Bertan V (1997) Meningiomas in childhood and adolescence: a report of 13 cases and review of the literature. Br J Neurosurg 11:501–507

    Article  CAS  PubMed  Google Scholar 

  15. Gezen F, Kahraman S, Canakci Z, Bedük A (2000) Review of 36 cases of spinal cord meningioma. Spine (Phila Pa 1976) 25:727–731

    Article  CAS  Google Scholar 

  16. Mekitarian Filho E, Horigoshi NK, Carvalho WB, Hirscheimer MR, Bresolin AU, Leme RJ, Flores JA (2010) Primary spinal meningioma in a 10-year-old boy. Arq Neuropsiquiatr 68:804–806

    Article  PubMed  Google Scholar 

  17. Brusius CV, Pereira Filho AA, Barnewitz JP, Putten AC, Pitta Pinheiro C, Aesse FF (2008) Intradural spinal meningioma in a 20-month-old female. Pediatr Neurosurg 44:247–252

    Article  PubMed  Google Scholar 

  18. Park HC, Sohn MJ, Kim EY, Han HS, Park HS (2000) Spinal clear cell meningioma presented with progressive paraparesis in infancy. Childs Nerv Syst 16:607–610

    Article  CAS  PubMed  Google Scholar 

  19. Watanabe M, Chiba K, Matsumoto M, Maruiwa H, Fujimura Y, Toyama Y (2001) Infantile spinal cord meningioma. Case illustration. J Neurosurg 94:334

    Article  CAS  PubMed  Google Scholar 

  20. Zaki SA, Ravi T, Shanbag P, Kalgutkar A (2009) Intraspinal meningioma in a 4-month-old infant. Neurol India 57:822–824

    Article  PubMed  Google Scholar 

  21. Colen CB, Rayes M, McClendon J Jr, Rabah R, Ham SD (2009) Pediatric spinal clear cell meningioma. Case report. J Neurosurg Pediatr 3:57–60

    Article  PubMed  Google Scholar 

  22. Gao X, Zhang R, Mao Y, Wang Y (2009) Childhood and juvenile meningiomas. Childs Nerv Syst 25:1571–1580

    Article  PubMed  Google Scholar 

  23. Menon G, Nair S, Sudhir J, Rao BR, Mathew A, Bahuleyan B (2009) Childhood and adolescent meningiomas: a report of 38 cases and review of literature. Acta Neurochir (Wien) 151:239–244

    Article  CAS  Google Scholar 

  24. Brokinkel B, Holling M, Spille DC, Heß K, Sauerland C, Bleimüller C, Paulus W, Wölfer J, Stummer W (2016) Surgery for meningioma in the elderly and long-term survival: comparison with an age- and sex-matched general population and with younger patients. J Neurosurg 3:1–11

    Google Scholar 

  25. Cohen-Gadol AA, Zikel OM, Koch CA, Scheithauer BW, Krauss WE (2003) Spinal meningiomas in patients younger than 50 years of age: a 21-year experience. J Neurosurg 98(3 Suppl):258–263

    PubMed  Google Scholar 

  26. Setzer M, Vatter H, Marquardt G, Seifert V, Vrionis FD (2007) Management of spinal meningiomas: surgical results and a review of the literature. Neurosurg Focus 23:E14

    Article  PubMed  Google Scholar 

  27. Maiti TK, Bir SC, Patra DP, Kalakoti P, Guthikonda B, Nanda A (2016) Spinal meningiomas: clinicoradiological factors predicting recurrence and functional outcome. Neurosurg Focus 41:E6

    Article  PubMed  Google Scholar 

  28. McCormick PC, Torres R, Post KD, Stein BM (1990) Intramedullary ependymoma of the spinal cord. J Neurosurg 72:523–532

    Article  CAS  PubMed  Google Scholar 

  29. Aghakhani N, David P, Parker F, Lacroix C, Benoudiba F, Tadie M (2008) Intramedullary spinal ependymomas: analysis of a consecutive series of 82 adult cases with particular attention to patients with no preoperative neurological deficit. Neurosurgery 62:1279–1285

    Article  PubMed  Google Scholar 

  30. Jeon JH, Hwang HS, Jeong JH, Park SH, Moon JG, Kim CH (2008) Spinal schwannoma; analysis of 40 cases. J Korean Neurosurg Soc 43:135–138

    Article  PubMed  PubMed Central  Google Scholar 

  31. Antunes A, Beck MF, Strapasson AC, Franciscatto AC, Franzoi M (2011) Extradural cavernous hemangioma of thoracic spine. Arq Neuropsiquiatr 69:720–721

    Article  PubMed  Google Scholar 

  32. Santoro A, Piccirilli M, Bristot R, di Norcia V, Salvati M, Delfini R (2005) Extradural spinal cavernous angiomas: report of seven cases. Neurosurg Rev 28:313–319

    Article  PubMed  Google Scholar 

  33. Rokni-Yazdi H, Sotoudeh H (2006) Prevalence of “dural tail sign” in patients with different intracranial pathologies. Eur J Radiol 60:42–45

    Article  PubMed  Google Scholar 

  34. Tien RD, Yang PJ, Chu PK (1991) “Dural tail sign”: a specific MR sign for meningioma? J Comput Assist Tomogr 15:64–66

    Article  CAS  PubMed  Google Scholar 

  35. Kotecha RS, Junckerstorff RC, Lee S, Cole CH, Gottardo NG (2011) Pediatric meningioma: current approaches and future direction. J Neurooncol 104:1–10

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We would like to thank all the patients’ parents who trusted us and all the physicians and staff who helped this study.

Author information

Authors and Affiliations

  1. Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China

    Liang Wu, Chenlong Yang, Tie Liu, Jun Yang & Yulun Xu

  2. Department of Neuropathology, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China

    Jingyi Fang

Authors
  1. Liang Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chenlong Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tie Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jingyi Fang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jun Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yulun Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yulun Xu.

Ethics declarations

Conflict of interest

The authors report no conflict of interest concerning the materials or methods used in this study or the findings described in this paper. No benefits in any form have been or will be received from any commercial party related directly or indirectly to the subject of this manuscript.

Ethical standards

This retrospective study was approved by Institutional Review Board of Beijing Tiantan Hospital, Capital Medical University.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wu, L., Yang, C., Liu, T. et al. Clinical features and long-term outcomes of pediatric spinal meningiomas. J Neurooncol 133, 347–355 (2017). https://doi.org/10.1007/s11060-017-2441-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11060-017-2441-9

Keywords

Search

Navigation