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Malignant peripheral nerve sheath tumor (MPNST) in the spine: a retrospective analysis of clinical and molecular prognostic factors

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Abstract

Spinal malignant peripheral nerve sheath tumors (MPNSTs) are relatively rare. There is little information published in the literature regarding this subject. The aim of this retrospective study was to evaluate factors that may affect the outcomes of patients with spinal MPNSTs by reviewing 43 patients with spinal MPNST who were treated in our hospital between 2001 and 2012. Univariate and multivariate analyses were performed to identify prognostic variables relative to patient and tumor characteristics, treatment modality and molecules. All 43 MPNST patients (25 men and 18 women; median age 49 years) underwent surgical resection, of whom 15 patients also underwent postoperative radiotherapy. Local recurrence was found in 21 (48.8 %) patients. Twenty-two (51.2 %) patients died during the follow-up periods with a median survival time of 49 months. The 5-year recurrence and survival rate was 53 and 44 % respectively. The statistical analyses suggested that high-grade malignancy and osteolytic destruction were closely associated with recurrence and death. A total of 38 cases accepted postoperative immunohistochemisty examine. S-100 was identified as an independent factor related to both recurrence and survival, adjusting for clinical factors. In conclusion, we confirmed that malignant grade and osteolytic destruction were the two independent factors for both recurrence and survival, while patients with S-100 protein negative had a higher recurrence rate and a lower survival rate.

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The authors declare no competing conflicts of interest.

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    Authors and Affiliations

    1. Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China

      Ting Wang, Huabin Yin, Shuai Han, Xinhai Yang, Jing Wang, Quan Huang, Wangjun Yan, Wang Zhou & Jianru Xiao

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    1. Ting Wang
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    2. Huabin Yin
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    3. Shuai Han
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    4. Xinhai Yang
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    5. Jing Wang
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    6. Quan Huang
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    7. Wangjun Yan
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    8. Wang Zhou
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    Correspondence to Wang Zhou or Jianru Xiao.

    Additional information

    Ting wang, Huabin Yin and Shuai Han contributed equally to this work, and all should be considered first author.

    Electronic supplementary material

    Below is the link to the electronic supplementary material. Supplemental Fig. 1 The S-100 IHC images and H&E images of three patients whose S-100 staining were negative (Case 3), weak positive (Case 35) and positive (Case 5) respectively.

    Supplementary material 1 (PNG 26,608 kb)

    Supplementary material 2 (DOCX 15 kb)

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    Wang, T., Yin, H., Han, S. et al. Malignant peripheral nerve sheath tumor (MPNST) in the spine: a retrospective analysis of clinical and molecular prognostic factors. J Neurooncol 122, 349–355 (2015). https://doi.org/10.1007/s11060-015-1721-5

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    • DOI: https://doi.org/10.1007/s11060-015-1721-5

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