Local field potentials (LFP) recorded in the olfactory bulb (OB) is largely generated in its local neural networks, is directly related to the processing of olfactory information, and is affected by various factors, including anesthetics. The effects of xylazine-tiletamine-zolazepam (XTZ) anesthesia on the spectral characteristics and coherence of LFP recorded from the dorsal surface of the OB in the frequency range 1–150 Hz for 2 h were studied using eight-electrode arrays in six domesticated adult male gray rats in chronic experimental conditions. The results showed that the most significant changes in LFP in the OB of rats under XTZ anesthesia occurred in the high γ frequency band. Statistically significant increases in the power (2–4 times) and coherence (up to 50%) of these frequencies was observed in the LFP of all animals within 10–15 min of onset of anesthesia. While the modal values of these frequencies were in the region of 70–80 Hz in waking, the corresponding frequencies after this duration of anesthesia were 110–130 Hz. During anesthesia there was a gradual shift in the modal value in the power distribution to the left, i.e., to lower frequencies (90–110 Hz), while total power (but not coherence) significantly decreased only when the animal came out of anesthesia.
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Translated from Sensornye Sistemy, Vol. 37, No. 1, pp. 65–77, January–March, 2023
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Kiroy, V.N., Kosenko, P.O., Shaposhnikov, P.D. et al. Changes in the Spectral Characteristics and Level of Coherence of Local Field Potentials in the Rat Olfactory Bulb during Xylazine-Tiletamine-Zolazepam Anesthesia. Neurosci Behav Physi 53, 1061–1071 (2023). https://doi.org/10.1007/s11055-023-01500-x
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DOI: https://doi.org/10.1007/s11055-023-01500-x