We report here studies of cognitive impairments at different periods of ontogeny in the offspring of rats with experimental preeclampsia modeled by replacement of drinking water with 1.8% sodium chloride solution from day 1 to day 21 of gestation. The offspring of females with complications of pregnancy, at both the early (40 days and three months) and late (six and 12 months) stages of individual development showed decreases in working memory in the novel object recognition test, degraded formation and retention of memory traces in the conditioned passive avoidance reflex test, and more marked amnesia in response to scopolamine at a dose of 1.75 mg/kg on testing for retention of memory traces. Oral treatment of the offspring of females with experimental preeclampsia at pubertal age (from day 40 to day 70 of life) with GABA derivatives succicard, salifen, and phenibut, and reference agent pantogam, promoted decreases in cognitive deficit in animals at different periods of postnatal development.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 106, No. 6, pp. 765–782, June, 2020.
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Muzyko, E.A., Tkacheva, G.A., Perfilova, V.N. et al. Cognitive Dysfunction in the Offspring of Rats with Experimental Preeclampsia at the Early and Late Stages of Ontogeny and Its Correction with GABA Derivatives. Neurosci Behav Physi 51, 372–380 (2021). https://doi.org/10.1007/s11055-021-01081-7
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DOI: https://doi.org/10.1007/s11055-021-01081-7