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The Developing Brain as a Target for Experimental Treatments in Modeling Pathological Processes

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This review addresses approaches to modeling impairments to brain function assessed in adulthood by targeted treatments during the perinatal period. Models of neuromental disorders linked with impairments to the dynamics of brain development are considered, along with models of diseases characteristic of older people. Pharmacological actions on the developing brain have been shown to induce delayed behavioral changes opposite to those induced by the drugs used when given to adult animals (for example, the development of a depressive state after perinatal administration of antidepressants). The history of the creation of such experimental models and their potential pathophysiological mechanisms are discussed. The significance of scientific research of this type for practical healthcare is demonstrated.

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  1. Laboratory of Physicochemical and Ecological Pathophysiology, Research Institute of General Pathology and Pathophysiology, Moscow, Russia

    N. B. Pankova

  2. Department of Higher Nervous Activity, Lomonosov Moscow State University, Moscow, Russia

    A. V. Latanov

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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol, 69, No, 4, pp, 413–436, July–August, 2019.

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Pankova, N.B., Latanov, A.V. The Developing Brain as a Target for Experimental Treatments in Modeling Pathological Processes. Neurosci Behav Physi 50, 552–566 (2020). https://doi.org/10.1007/s11055-020-00936-9

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