This review presents data on the characteristics of the reorganization of the hippocampus associated with impairment to neurogenesis in epileptiform states of different etiologies. Data on the effects of convulsive states of different severities and frequencies on the levels of proliferation, migration, and insertion of new cells into the hippocampal neural network are presented and anomalies in newly formed granule cells are described. The focus is placed on possible explanations of existing contradictions in anybody assessment of the importance of neurogenesis in epilepsy.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 104, No. 10, pp. 1152–1162, October, 2018.
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Nasluzova, E.V., Glazova, M.V. & Chernigovskaya, E.V. Hippocampal Neurogenesis in Epileptogenesis. Neurosci Behav Physi 50, 239–244 (2020). https://doi.org/10.1007/s11055-019-00892-z
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DOI: https://doi.org/10.1007/s11055-019-00892-z