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Expression of Serotonin Transporter Protein in the Dorsal Raphe Nucleus during the Early Postnatal Period in Rats

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We report here our studies on expression of serotonin transporter protein (5-HTT) in the dorsal, ventral, and lateral subnuclei of the dorsal raphe nucleus (DRN) in Wistar rats (n = 15) during the early postnatal period. Histological methods were used, along with the immunocytochemical reaction for 5-HTT. Most neurons in the subnuclei studied here were found to express 5-HTT intensely on day 5 of the postnatal period. However, by day 10, the level of expression decreased sharply, though there was a subsequent age-related (by day 20) increase in expression, with a rise in the number of cells in the 5-HTT-positive neuron population and an increase in the density of the plexus formed by their processes. These changes in 5-HTT expression provide evidence of different levels of the functional activity of serotonin in the DRN during the early postnatal period.

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Authors and Affiliations

  1. Laboratory for Nervous System Ontogeny, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    L. I. Khozhai

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  1. L. I. Khozhai
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Correspondence to L. I. Khozhai.

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Translated from Morfologiya, Vol. 148, No. 4, pp. 43–45, July–August, 2015.

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Khozhai, L.I. Expression of Serotonin Transporter Protein in the Dorsal Raphe Nucleus during the Early Postnatal Period in Rats. Neurosci Behav Physi 46, 504–506 (2016). https://doi.org/10.1007/s11055-016-0266-1

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  • DOI: https://doi.org/10.1007/s11055-016-0266-1

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