Aim of study. Traumatic neuropathy is a current problem in contemporary neurology because of the frequent occurrence of severe neurological deficit and the poor prognosis for recovery. The aim of the present work was to study the effects of the anticholinesterase agent Neuromidin and transspinal magnetic stimulation on neuroplastic axon changes in the rat sciatic nerve in experimental neurotmesis. Materials and methods. Animals (20 rats) were divided into three groups: group 1 (controls) received no treatment; animals of group 2 received rhythmic transspinal magnetic stimulation of intensity 0.8–1.0 T, frequency 3 Hz, and duration 3–5 min daily for one month; animals of group 3 were treated with i.m. injections of Neuromidin at a dose of 0.035 mg/day. Results and conclusions. The results obtained here on the recovery of myelin, axon, and nodes of Ranvier structures in myelinated fibers and lemmocyte (Schwann cell) ultrastructure in experimental animals treated with both magnetic stimulation and Neuromidin led to the conclusion that the use of both methods stimulated compensatory-restorative processes in traumatic neuropathies.
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Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 114, No. 6, Iss. I, pp. 57–62, June, 2014.
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Zhivolupov, S.A., Rashidov, N.A., Onishchenko, L.S. et al. Comparison of the Influences of Neuromidin and Magnetic Stimulation on Neuroplasticity in Experimental Traumatic Neuropathy. Neurosci Behav Physi 46, 110–115 (2016). https://doi.org/10.1007/s11055-015-0206-5
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DOI: https://doi.org/10.1007/s11055-015-0206-5