The effects of rhythmic light stimulation on the postnatal development of the visual system were studied in relation to the formation of Meynert neurons in field 17 and the posteromedial area of the lateral suprasylvian sulcus (PMLS) in kittens reared with exposure to flashing light (frequency 15 Hz). Neuron body cross-sectional area and cytochrome oxidase (CO) activity levels were measured in the visual cortex of control (n = 6) and stimulated (n = 6) animals. Increases in the level of CO activity were seen in Meynert cells in field 17 and the PMLS area, by about 37%. There was also a decrease in the cross-sectional area of the bodies of Meynert neurons located in the PMLS, by 20% compared with normal. The existence of functional impairments of the Y conducting channel in stimulated animals and the possibility that binocular vision is suppressed are discussed.
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References
N. S. Merkul’eva and F. N. Makarov, “Effects of short- and long-term stimulation with flashing light on the cytochrome oxidase system of modules in layer IV of the primary visual cortex in kittens,” Ros. Fiziol. Zh., 94, No. 5, 557–565 (2008).
N. S. Merkul’eva, A. A. Mikhalkin, N. I. Nikitina, and F. N. Makarov, “Development of connections in the primary visual cortex with the movement analysis center: the role of visual context,” Morfologiya, 140, No. 6, 24–31 (2011).
V. Chan-Palay, S. L. Palay, and S. M. Billings-Gagliardi, “Meynert cells in the primate visual cortex,” J. Neurocytol., 3, No. 5, 631–658 (1974).
P. L. Gabbott, K. A. Martin, and D. Whitteridge, “Connections between pyramidal neurons in layer 5 of cat visual cortex (area 17),” J. Comp. Neurol., 259, No. 3, 364–381 (1987).
C. N. Levelt and M. Hübener, “Critical-period plasticity in the visual cortex,” Annu. Rev. Neurosci., 35, 309–330 (2012).
H. Li, M. Fukuda, M. Tanifuji, and K. S. Rockland, “Intrinsic collaterals of layer 6 Meynert cells and functional columns in primate V1,” Neuroscience, 120, No. 4, 1061–1069 (2003).
J. H. R. Mansell, “Functional visual streams,” Curr. Opin. Neurobiol., 2, No. 4, 506–510 (1992).
H. Nakagama and S. Tanaka, “Self-organization model of cytochrome oxidase blobs and ocular dominance columns in the primary visual cortex,” Cereb. Cortex, 14, No. 4, 376–386 (2004).
B. R. Payne and A. Peters, “Cytochrome oxidase patches and Meynert cells in monkey visual cortex,” Neuroscience, 28, No. 2, 353–363 (1989).
A. Rokszin, Z. Márkus, G. Braunitzer, et al., “Visual pathways serving motion detection in the mammalian brain,” Sensors (Basel), 10, No. 4, 3218–3242 (2010).
D. A. Winfield, “The effect of visual deprivation upon the Meynert cell in the striate cortex of the cat,” Brain Res., 281, No. 1, 53–57 (1982).
M. T. Wong-Riley, “Changes in the visual system of monocularly sutured or enucleated cats demonstrated with cytochrome oxidase histochemistry,” Brain Res., 171, No. 1, 1–28 (1979).
M. T. Wong-Riley, “Cytochrome oxidase: an endogenous metabolic marker for neuronal plasticity,” Trends Neurosci., 12, No. 3, 94–101 (1989).
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Translated from Morfologiya, Vol. 145, No. 2, pp. 12–15, March–April, 2014.
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Merkul’eva, N.S., Mikhalkin, A.A. & Makarov, F.N. Development of Meynert Cells in the Cat Visual Cortex in Conditions of Stimulation with Flashing Light. Neurosci Behav Physi 45, 363–366 (2015). https://doi.org/10.1007/s11055-015-0082-z
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DOI: https://doi.org/10.1007/s11055-015-0082-z