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Assessment of Long-Term Sensorimotor Deficit after Cerebral Ischemia/Hypoxia in Neonatal Rats

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MRI studies showed that cerebral ischemia/hypoxia in neonatal rat pups applied using the Levine–Rice method induced unilateral lesions in the cerebral cortex, striatum, and hippocampus. Unilateral ischemic lesions led to long-term sensorimotor and behavioral impairments at 90–115 days after surgery on testing the animals in a battery of tests consisting of the cylinder, tapering beam, Montoya, and paw-placing tests. This combination of tests, along with MRI studies, provided reliable evaluation of long-term sensorimotor impairments in adult animals subjected to trauma in the neonatal period.

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Authors and Affiliations

  1. A. N. Belozerskii Science Research Institute of Physicochemical Biology, M. V. Lomonosov Moscow State University, Moscow, Russia

    D. N. Silachev, M. I. Shubina, S. S. Yankauskas, V. P. Mkrtchyan & D. B. Zorov

  2. Faculty of Bioengineering and Bioinformatics, M. V. Lomonosov Moscow State University, Moscow, Russia

    S. S. Yankauskas & V. N. Manskikh

  3. Faculty of Basic Medicine, M. V. Lomonosov Moscow State University, Moscow, Russia

    M. V. Gulyaev

Authors
  1. D. N. Silachev
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  2. M. I. Shubina
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  3. S. S. Yankauskas
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  4. V. P. Mkrtchyan
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  5. V. N. Manskikh
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  6. M. V. Gulyaev
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  7. D. B. Zorov
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Correspondence to D. B. Zorov.

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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 63, No. 3, pp. 405–416, May–June, 2013.

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Silachev, D.N., Shubina, M.I., Yankauskas, S.S. et al. Assessment of Long-Term Sensorimotor Deficit after Cerebral Ischemia/Hypoxia in Neonatal Rats. Neurosci Behav Physi 44, 879–887 (2014). https://doi.org/10.1007/s11055-014-9996-0

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