The effects of the 5-HT2 receptor agonist DOI ((±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride) and the antagonist ketanserin (ketanserin tartrate salt) were studied in rats using the right to choose” reinforcement value method. Depending on the preferred food reinforcement choice, the rats were divided into self-controlled (selecting the more valuable but delayed reinforcement) and impulsiv (preferring low-value but rapid reinforcement) groups. Animals received intraperitoneal DOI or ketanserin at a dose of 0.2 mg/kg 1 h before testing. Behavioral parameters were measured – the number of pressing of the two pedals, the latent periods of opening the screen and pressing the pedal, and the number of missed screen shifting/pedal pressing reactions. Administration of ketanserin produced a statistically significant increase in selection of the low-value, immediate reinforcement in the group of impulsive animals but did not alter the behavior of self-controlled animals. After administration of DOI, neither of the groups showed any statistically significant changes in reinforcement choice, though studies of the actions of this agent demonstrated statistically significant reductions in impulsivity in all animals, regardless of division into typological groups. In some cases, DOI decreased the number of missed reactions, while ketanserin decreased the latent period of responses.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
G. A. Grigor’yan, “Serotonin and impulsivity,” Zh. Vyssh. Nerv. Deyat., 61, No. 3, 261–273 (2011)
M. I. Zaichenko and G. Kh. Merzhanova, “Effects of blockade of D1/D2 dopamine receptors on behavior in rats with different levels of impulsivity and self-control,” Zh. Vyssh. Nerv. Deyat., 61, No. 5, 1–10 (2011)
M. I. Zaichenko, G. Kh. Merzhanova, and G. L. Vanetsian, “Effects of selective 5-HT1A receptor ligands on impulsive and self-controlled behavior in rats,” Zh. Vyssh. Nerv. Deyat., 62, No. 4, 465–474 (2012).
A. Blokland, A. Sik, and C. Lieben, “Evaluation of DOI, 8-OH-DPAT, eticlopride and amphetamine on impulsive responding in a reaction time task in rats,” Behav. Pharmacol., 16, No. 2, 93–100 (2005).
V. Cornea-Hebert, M. Riad, C. Wu, et al., “Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat,” J. Comp. Neurol., 408, No. 2, 187–209 (1999).
Y. Charnay and L. Leger, “Brain serotoninergic circuitries,” Dialog. Clin. Neurosci., 12, No. 4, 6471–6487 (2010).
T. J. Crow and J. F. W. Deakin, “Affective change and the mechanism of reward and punishment: a neurological-hormonal hypothesis,” in: Developments in Psychiatry, G. Perris, G. Struwe, and B. Jansson (eds.), Elsevier, Amsterdam (1981), No. 5, pp. 536–541.
J. W. Dalley, D. E. Theobald, D. M. Eagle, et al., “Deficits in impulse control associated with tonically elevated serotonergic function in rat prefrontal cortex,” Neuropsychopharmacology, No. 6, 716–728 (2002).
J. L. Evenden, “Varieties of impulsivity,” Psychopharmacology (Berlin), 146, No. 4, 348–361(1999).
J. L. Evenden, and C. N. Ryan, “The pharmacology of impulsive behaviour in rats. VI. The effects of ethanol and selective serotoner-gic drugs on response choice with varying delays of reinforcement,” Psychopharmacology (Berlin), 146, No. 4, 413–421 (1999)
C. T. Fischette, B. Nock, and K. Renner, “Effects of 5,7-dihydroxytryptamine on serotonin 1 and serotonin 2 receptors throughout the rat central nervous system using quantitative autoradiography,” Brain Res., 421, No. 1–2, 263–279 (1987).
P. J. Fletcher, M. Tampakeras, J. Sinyard, and G. A. Higgins, “Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test,” Psychopharmacology (Berlin), 195, No. 2, 223–234 (2007).
M. Hadamitzky, M. Feja, T. Becker, and M. Koch, “Effects of acute systemic administration of serotonin 2A/C receptor ligands in a delay-based decision-making task in rats,” Behav. Pharmacol., 20, No. 5–6, 415–423 (2009).
M. Y. Ho, S. S. Al-Zahrani, A. S. Al-Ruwaitea, et al., “5-Hydroxytryptamine and impulse control: prospects for behavioral analysis,” J. Psychopharmacol., 12, No. 1, 68–78 (1998).
T. Koskinen, S. Ruotsalainen, T. Puumala, et al., “Activation of 5- HT2A receptors impairs response control of rats in a five-choice serial reaction time task,” Neuropharmacology, 39, No. 3, 471–481 (2000).
T. Koskinen and J. Sirviö, “Studies on the involvement of the dopaminergic system in the 5-HT2 agonist (DOI)-induced premature responding in a five-choice serial time task,” Brain Res. Bull., 54, No. 1, 65–75 (2001).
A. W. Logue, “Research on self-control: An integrating framework,” Behav. Brain Sci., 11, 665–709 (1988).
D. A. McCormick, “Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity,” Prog. Neurobiol., 39, No. 4, 337–338 (1992).
K. Miyazaki, K. W. Miyazaki, and K. Doya, “Activation of dorsal raphe serotonin neurons underlies waiting for delayed rewards,” J. Neurosci., 31, No. 2, 469–479 (2011).
F. Passetti, J. W. Dalley, and T. W. Robbins, “Double dissociation of serotonergic and dopaminergic mechanisms on attentional performance using a rodent five-choice reaction time task,” Psychopharmacology (Berlin), 165, No. 2, 136–145 (2003).
E. Pehek, C. Nocjar, B. Roth, et al., “Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress and druginduced dopamine release in the rat medial prefrontal cortex,” Neuropsychopharmacology, 31, No. 2, 265–277 (2006).
M. Pompeiano, J. M. Palacios, and G. Mengod, “Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors,” Mol. Brain Res., 23, No. 1–2, 163–178 (1994).
T. Puumila and J. Sirviö, “Changes in activities of dopamine and serotonin system in the frontal cortex underlie poor choice accuracy and impulsivity in rats in an attention task,” Neuroscience, 83, No. 2, 489–499 (1998).
T. W. Robbins, “Arousal system and attentional processes,” Biol. Psychol., 45, No. 1–3, 57–71 (1997).
L. Stein, C. D. Wise, and B. D. Berger, “Anti-anxiety action of benzodiazepines: decrease in activity of serotonin neurons in the punishment system,” in: The Benzodiazepines, E. Costa and P. Greengard (eds.), Raven Press, New York (1973), pp. 299–326.
M. R. Spoont, “Modulatory role of serotonin in neural information processing: implications for human psychopathology,” Psychol. Bull., 112, No. 2, 330–350 (1992).
J. C. Talpos, L. S. Wilkinson, and T. W. Robbins, “A comparison of multiple 5-HT receptors in two tasks measuring impulsivity,” J. Psychopharmacol., 20, No. 1, 47–58 (2006).
C. A. Winstanley, “The utility of rat models of impulsivity in developing pharmacotherapies for impulse control disorders,” Br. J. Pharmacol., 164, No. 4, 1301–1321 (2011).
C. A. Winstanley, D. E. Theobald, J. W. Dalley, et al., “5-HT2A and 5-HT2C receptor antagonists have opposing effects on a measure of impulsivity: interactions with global 5-HT depletion,” Psychopharmacology (Berlin), 176, No. 3–4, 376–385 (2004).
D. Wright, K. Seroogy, K. Lundgren, et al., “Comparative localization of serotonin 1A, 1C and 2 receptor subtype mRNA in rat brain,” J. Comp. Neurol., 351, No. 3, 357–373 (1995).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 63, No. 2, pp. 246–255, March–April, 2013.
Rights and permissions
About this article
Cite this article
Zaichenko, M.I., Merzhanova, G.K. & Vanetsian, G.L. Effects of a 5-HT2 Receptor Agonist and an Antagonist on the Behavior of Rats with Different Choices of Reinforcement Value. Neurosci Behav Physi 44, 506–512 (2014). https://doi.org/10.1007/s11055-014-9940-3
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11055-014-9940-3