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Efficient antibacterial study based on near-infrared excited metal–organic framework nanocomposite

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Abstract

Near-infrared light-triggered UCNR@ZIF-67 antibacterial nanomaterials were constructed by combining β-NaYF4:Yb,Tm,Gd up-conversion nanorods (UCNRs) with near-infrared light response and Zeolitic Imidazolate Frameworks (ZIF-67) through the layer-by-layer self-assembly method. The optical properties, structure, composition, and morphology of UCNR@ZIF-67 were investigated by using UV–vis diffuse reflectance spectroscopy, X-ray diffraction and transmission electron microscopy. Reactive oxidizing species (ROS) detection indicated that the UCNR@ZIF-67 owned a good photodynamic efficacy. UCNR@ZIF-67 exhibited low toxicity and good biocompatibility by CCK-8 method. About 99.3% of E. coli and 99.1% of S. aureus were killed by UCNR@ZIF-67 under 980-nm laser irradiation for 25 min (1.0 W/cm2). Under 980-nm laser excitation, UCNRs generated ultraviolet and visible light to activate ZIF-67 and produced a large number of electron/hole pairs (e−/h+), which can react with O2 and H2O to produced ROS for antibacterial applications.

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Funding

This work was supported by a grant from the National Natural Science Foundation of China (82204176, 12175103), the Natural Science Foundation of Hunan Province (2021JJ40454, 2023JJ50127), the research fund of Nuclear Materials of China Atomic Energy Authority (ICNM-2023-ZH-22), and the Research Foundation of Education Bureau of Hunan Province (22B0432).

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Authors and Affiliations

  1. School of Public Health, Hengyang Medical School, University of South China, Hengyang, 421001, People’s Republic of China

    Ting He, Yu Liu, Shaoqi Zhang, Chunhui Meng, Le Li, Hui Wang & Deshuai Zhen

  2. Hunan Key Laboratory of Typical Environment Pollution and Health Hazards, University of South China, Hengyang, 421001, People’s Republic of China

    Ting He, Shaoqi Zhang, Chunhui Meng, Le Li, Hui Wang & Deshuai Zhen

  3. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People’s Republic of China

    Yu Liu & Deshuai Zhen

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  1. Ting He
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He, T., Liu, Y., Zhang, S. et al. Efficient antibacterial study based on near-infrared excited metal–organic framework nanocomposite. J Nanopart Res 25, 160 (2023). https://doi.org/10.1007/s11051-023-05810-6

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