Abstract
The main goal of this work consists of synthesis of new magnetic multifunctional nanoplatforms based on Fe@FePt core, with principal target in applications regarding the capture and separation of amino acids. These expectations were fulfill by attaching amino functional groups on the core surface. Therefore, our Fe@FePt@SiO2@NH2 core-shell nanoparticles could serve as promising multifunctional nanoplatforms for molecular recognition and magnetic separation. In this way, these nanoplatforms are capable to catch the amino acids (lysine, cysteine, and alanine) from liquid media. The properties of the obtained nanoparticles were evaluated, and the retention level was determined by high-performance liquid chromatography. It was found that for a mass ratio of 10 and 40 between nanoparticles and amino acids, the lysine is best retained from liquid media. For a mass ratio of 20, the best level of retention was realized for alanine. The most responsive was the lysine followed by the alanine and then by the cysteine.
Graphical abstract
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Data availability
The raw/processed data required to reproduce these findings cannot be shared at this time as the data also forms part of an ongoing study.
References
Hong R, Fischer NO, Emrick T, Rotello VM (2005) Surface PEGylation and ligand exchange chemistry of FePt nanoparticles for biological applications. Chem Mater 17:4617–4621. https://doi.org/10.1021/cm0507819
Kamgar A, Hassanajili S, Karimipourfard G (2018) Fe3O4@SiO2@MPS core/shell nanocomposites: The effect of the core weight on their magnetic properties and oil separation performance. J Environ Chem Eng. 6:3034–3040. https://doi.org/10.1016/j.jece.2018.04.057
Lee DC, Mikulec FV, Pelaez JM, Koo B, Korgel BA (2006) Synthesis and magnetic properties of silica-coated FePt nanocrystals. J Phys Chem B. 110:11160–11166. https://doi.org/10.1021/jp060974z
Li X, Liu D, Song S, Zhang H (2014) Fe3O4@SiO2@TiO2@Pt hierarchical core−shell microspheres: controlled synthesis, enhanced degradation system, and rapid magnetic separation to recycle. Cryst Growth Des 14:5506–5511. https://doi.org/10.1021/cg501164c
Liu Y, Yang K, Cheng L, Zhu J, Ma X, Xu H, Li Y, Guo L, Gu H, Liu Z (2013) PEGylated FePt@Fe2O3 core-shell magnetic nanoparticles: potential theranostic applications and in vivo toxicity studies. Nanomed-Nanotechnol. 9(7):1077–1088. https://doi.org/10.1016/j.nano.2013.02.010
Ma C, Li C, He N, Wang F, Ma N, Zhang L, Lu Z, Ali Z, Xi Z, Li X, Liang G, Liu H, Deng Y, Xu L, Wang Z (2012) Preparation and characterization of monodisperse core–shell Fe3O4@SiO2 microspheres and its application for magnetic separation of nucleic acids from E. coli BL21. J Biomed Nanotechnol. 8:1000–1005. https://doi.org/10.1166/jbn.2012.1454
Majeed J, Jayakumar OD, Salunke HG, Mandal BP, Lawes G, Naikc R, Tyagi AK (2013) Multifunctional hybrid structures of ferromagnetic FePt and ferroelectric BaTiO3 nanoparticles: facile synthesis and characterization. RSC Adv. 3:596–602. https://doi.org/10.1039/C2RA21972G
Shao M, Ning F, Zhao J, Wei M, Evans DG, Duan X (2012) Preparation of Fe3O4@SiO2@layered double hydroxide core−shell microspheres for magnetic separation of proteins. J Am Chem Soc 134:1071–1077. https://doi.org/10.1021/ja2086323
Sun H, Chen X, Chen D, Dong M, Fu X, Li Q, Liu X, Wu Q, Qiu T, Wan T, Li S (2012) Influences of surface coatings and components of FePt nanoparticles on the suppression of glioma cell proliferation. In J Nanomed. 7:3295–3307. https://doi.org/10.2147/IJN.S32678
Wang J, Zheng S, Shao Y, Liu J, Xu Z, Zhu D (2010) Amino-functionalized Fe3O4@SiO2 core–shell magnetic nanomaterial as a novel adsorbent for aqueous heavy metals removal. J Colloid Interf Sci. 349:293–299. https://doi.org/10.1016/j.jcis.2010.05.010
Xu C, Xu K, Gu H, Zhong X, Guo Z, Zheng R, Zhang X, Xu B (2004) Nitrilotriacetic acid-modified magnetic nanoparticles as a general agent to bind histidine-tagged proteins. J Am Chem Soc. 126:3392–3393. https://doi.org/10.1021/ja031776d
Zhang G, Feng J, Lu L, Zhang B, Cao L (2010) Fluorescent magnetic nanoprobes: Design and application for cell imaging. J Colloid Interf Sci. 351:128–133. https://doi.org/10.1016/j.jcis.2010.07.056
Funding
This work was supported by Romanian Ministry of Research and Innovation, Core Program, Project PN 19 35 02 03 (36 N/13.02.2019).
Author information
Authors and Affiliations
Contributions
Adina Stegarescu: methodology, investigation, results correlation, writing original draft; Simona Guțoiu: investigation, results correlation, writing original draft; Ildiko Lung: investigation, results correlation, conceptualization; Ocsana Opris: investigation, results correlation; Cristian Leoștean: investigation, results correlation; Ovidiu Pană: conceptualization, investigation, results correlation; Lucian Barbu: investigation, results correlation; Maria-Loredana Soran: conceptualization, review, supervision, investigation, results correlation
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Stegarescu, A., Guțoiu, S., Lung, I. et al. Synthesis and characterization of Fe@FePt@SiO2@NH2 nanoplatform for amino acids recognition. J Nanopart Res 23, 91 (2021). https://doi.org/10.1007/s11051-021-05197-2
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s11051-021-05197-2