Abstract
A protocol is described for an efficient transamidation of amides with amines in the presence of mesoporous silica nanoparticles (MSNs). The latter is used as a green, heterogeneous, and recyclable nanocatalyst, under solvent-free conditions. Following this protocol, a wide range of aromatic, aliphatic, and cyclic/acyclic primary or secondary amines are used in synthesis of a series of amides with good to excellent yields (65–96%). MSNs is characterized by using scanning electron microscopy (SEM), transmission electron microscopy (TEM), small-angle powder X-ray diffraction (XRD), nitrogen adsorption-desorption analysis, and FT-IR spectroscopy. The metal/solvent-free condition, easy work up, high purity of the products, recyclability, and environmentally-friendly nature of the catalyst are the attractive features of this methodology.
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Mohamad Z. Kassaee is a visiting scholar (sabbatical)
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Eidi, E., Kassaee, M.Z. & Nasresfahani, Z. Mesoporous silica nanoparticles in an efficient solvent-free transamidation of carboxamides with amines: an exhibition of a green recyclable nanocatalyst. J Nanopart Res 20, 99 (2018). https://doi.org/10.1007/s11051-018-4195-5
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DOI: https://doi.org/10.1007/s11051-018-4195-5