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Magnetic nanoparticles coated with dimercaptosuccinic acid: development, characterization, and application in biomedicine

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Abstract

This review intends to summarize some of the results achieved in the development of magnetic nanoparticles coated with anionic ligands, specifically dimercaptosuccinic acid applied in the biomedical area. We describe synthetic routes used to produce iron oxide-based magnetic nanoparticles, subsequently coated with DMSA as well as functionalization strategies for specific purposes with polymers, antibodies, and cytokines. Finally, we have collected data on biological interactions of DMSA-coated nanoparticles in vitro and in vivo, in particular cell interaction process, pharmacokinetics, and biodistribution in different animal models and their promising applications in drug delivery, NMR imaging, hyperthermia, nanothermometry, magnetic separation, and bioremediation.

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Acknowledgments

AR holds a predoctoral fellowship from a CSIC-CITMA collaborative project (B01CU2009; ICMM, 2011–2014) and a short-term fellowship from CNPq (DTI-2; 383934/2013-3). This work was partially supported by the Spanish Ministry of Economy and Competitiveness (Project MAT2011-23641).

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Authors and Affiliations

  1. Departamento de Biomateriales y Materiales Bioinspirados, Instituto de Ciencia de Materiales de Madrid, CSIC, Sor Juana Inés de la Cruz 3, Cantoblanco, 28049, Madrid, Spain

    Amalia Ruiz & María del Puerto Morales

  2. Centro de Estudios Avanzados de Cuba, San Antonio de Los Baños km 3½, La Habana, Cuba

    Amalia Ruiz

  3. Instituto de Física, Universidade de Brasilia, Brasília, DF, 70910-900, Brazil

    Paulo César Morais

  4. School of Automation, Huazhong University of Science and Technology, Wuhan, 430074, China

    Paulo César Morais

  5. Departamento de Genética e Morfologia, Institute of Biological Sciences, Universidade de Brasilia, Brasília, DF, 70910-900, Brazil

    Ricardo Bentes de Azevedo & Zulmira G. M. Lacava

  6. Departamento de Biología, Universidad Autónoma de Madrid, Darwin 2, Cantoblanco, 28049, Madrid, Spain

    Angeles Villanueva

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  1. Amalia Ruiz
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  2. Paulo César Morais
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  3. Ricardo Bentes de Azevedo
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  4. Zulmira G. M. Lacava
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  5. Angeles Villanueva
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  6. María del Puerto Morales
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Correspondence to María del Puerto Morales.

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Guest Editors: Carlos Lodeiro Espiño, José Luis Capelo Martinez

This article is part of the topical collection on Composite Nanoparticles

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Ruiz, A., Morais, P.C., Bentes de Azevedo, R. et al. Magnetic nanoparticles coated with dimercaptosuccinic acid: development, characterization, and application in biomedicine. J Nanopart Res 16, 2589 (2014). https://doi.org/10.1007/s11051-014-2589-6

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