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Molecular tools are crucial for malaria elimination

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Abstract

The eradication of Plasmodium parasites, responsible for malaria, is a daunting global public health task. It requires a comprehensive approach that addresses symptomatic, asymptomatic, and submicroscopic cases. Overcoming this challenge relies on harnessing the power of molecular diagnostic tools, as traditional methods like microscopy and rapid diagnostic tests fall short in detecting low parasitaemia, contributing to the persistence of malaria transmission. By precisely identifying patients of all types and effectively characterizing malaria parasites, molecular tools may emerge as indispensable allies in the pursuit of malaria elimination. Furthermore, molecular tools can also provide valuable insights into parasite diversity, drug resistance patterns, and transmission dynamics, aiding in the implementation of targeted interventions and surveillance strategies. In this review, we explore the significance of molecular tools in the pursuit of malaria elimination, shedding light on their key contributions and potential impact on public health.

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Funding

This work was supported by the Science and Engineering Research Board (SERB), India, under Award Number SRG/2022/000705 (HG). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funders.

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Authors and Affiliations

  1. Department of Biotechnology, Institute of Applied Sciences & Humanities, GLA University, Mathura, Uttar Pradesh, India

    Himanshu Gupta & Sonal Sharma

  2. Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences, Institute of Biochemistry and Genetics, Ufa, 450054, Russia

    Irina Gilyazova

  3. Bashkir State Medical University, Ufa, 450008, Russia

    Irina Gilyazova

  4. SDM College of Medical Sciences and Hospital, Shri Dharmasthala Manjunatheshwara (SDM) University, Manjushree Nagar, Sattur, Dharwad, 580009, Karnataka, India

    Kapaettu Satyamoorthy

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  1. Himanshu Gupta
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HG and KS conceived the idea. SS, IG, and HG collected the literature. HG and SS generated the first draft of the study. HG, IG, and KS critically reviewed the manuscript. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Himanshu Gupta.

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Gupta, H., Sharma, S., Gilyazova, I. et al. Molecular tools are crucial for malaria elimination. Mol Biol Rep 51, 555 (2024). https://doi.org/10.1007/s11033-024-09496-4

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