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AMPK, a key molecule regulating aging-related myocardial ischemia-reperfusion injury

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Abstract

Aging leads to the threat of more diseases to the biological anatomical structure and the decline of disease resistance, increasing the incidence and mortality of myocardial ischemia–reperfusion injury (MI/RI). Moreover, MI/RI promotes damage to an aging heart. Notably, 5′-adenosine monophosphate-activated protein kinase (AMPK) regulates cellular energy metabolism, stress response, and protein metabolism, participates in aging-related signaling pathways, and plays an essential role in ischemia–reperfusion (I/R) injury diseases. This study aims to introduce the aging theory, summarize the interaction between aging and MI/RI, and describe the crosstalk of AMPK in aging and MI/RI. We show how AMPK can offer protective effects against age-related stressors, lifestyle factors such as alcohol consumption and smoking, and hypertension. We also review some of the clinical prospects for the development of interventions that harness the effect of AMPK to treat MI/RI and other age-related cardiovascular diseases.

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Acknowledgements

Fund of Role and mechanism of stem cell exosome miR-let-7g targeting inhibition of NAT1/IGF2/IGF2R pathway; Foundation of Department of finance of Jilin Province, 2020 Jilin Province Health special discipline talent development project, Number: 2020SCZT018/fund of Study on the mechanism of action of Shexiang xinnaole tablet in coronary heart disease and the key technology of quality improvement; Foundation of Jilin Provincial Department of science and technology, Number: 20190304103YY

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  1. Department of Cardiology, Second Hospital of Jilin University, No.218 Ziqiang Street, Changchun, 130041, China

    Xiaorui Yin, Ziyuan Guo & Chunli Song

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  1. Xiaorui Yin
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Yin, X., Guo, Z. & Song, C. AMPK, a key molecule regulating aging-related myocardial ischemia-reperfusion injury. Mol Biol Rep 51, 257 (2024). https://doi.org/10.1007/s11033-023-09050-8

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