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Drug-herb combination therapy in cancer management

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Abstract

Cancer is the second leading cause of fatality all over the world. Various unwanted side effects are being reported with the use of conventional chemotherapy. The plant derived bioactive compounds are the prominent alternative medicinal approach for reduction of chemotherapy associated side effects. The data is collected from Pubmed, Sci-hub, Google scholar, and Research gate were systematically searched up to year 2020. Several herbal drugs have been investigated and found with grateful anti-cancer potentials hence, it can be used in combination with chemotherapy for the depletion of associated side-effects. Herbal drugs and their extracts contain a mixture of active ingredients, which show interactions within themselves and along with chemotherapeutic agents to show either synergistic or antagonistic therapeutic effects. Therefore, it is necessary to develop alternative treatment to control chemotherapy associated side-effects. In this review, we discussed some of the significant chemical compounds, which could be efficient against cancer. This review focuses on the different herbal drugs that play an important role in the treatment of cancer and its associated side-effects. This study aimed to evaluate the efficacy of herbal treatment in combination with chemotherapy for cancer treatment.

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Availability of data and materials

Data has been collected from google scholar, pubmed, sci hub.

Code availability

NA.

Abbreviations

AA:

Arachidonic acid

CICI:

Chemotherapy-induced cognitive impairment, CIPN, Chemotherapy induced peripheral neuropathy

COX-2:

Cyclo-oxygenase-2

IFs:

Interferons

ILs:

Interleukins

iNOS:

Inducible nitric oxide synthase, LOX, liopxygenase

MCP-1:

Monocyte chemotactic protein-1

MIP-1α:

Monocyte inflammatory protein-1, PI3K, phosphoinositide 3-kinase

QoL:

Quality of life

WHO:

World Health Organization

CVS:

Cardiovascular system

GIT:

Gastrointestinal tract

5-FU:

5-Fluorouracil

NF-κB:

Nuclear factor-kappa B

MAPK:

Mitogen-activated protein kinase

EGF:

Epidermal growth factor

COX-2:

Cyclooxygenase-2

TNF-α:

Tumor necrosis factor-alpha

STAT3:

Signal transducer and activator of transcription 3

IL:

Interleukin

NO:

Nitric oxide

CML:

Chronic myeloid leukemia

PPD:

Protopanaxadiol

PPT:

Protopanaxatriol

HATs:

Histone acetyltransferases

HDAC:

Histone deacetylase

VEGF:

Vascular endothelial growth factor

MDR:

Multidrug resistance

MRPs:

Multidrug resistance-associated proteins

Pgp:

P-glycoprotein

CRF:

Cancer related fatigue

mTOR:

Mammalian target of rapamycin kinase

ERK:

Extracellular signal regulated kinase

MEK:

Mitogen activated protein kinase kinase

PKB:

Protein kinase B

ROS:

Reactive oxygen species

LPO:

Lipid peroxidation

AUC:

Area under the curve

CRC:

Colorectal cancer

IGFs:

Insulin like growth factor

PDGF:

Platelet derived growth factor

IGF-1:

Insulin like growth factor-1

IGFBPs:

IGF binding proteins

Cyt-c:

Cytochrome c

PLA2s:

Phospholipase A2

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Funding

This work was supported by DST SERB under EEQ grant with File No. EEQ/2019/000690.

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Authors and Affiliations

  1. Department of Pharmacology, ISF College of Pharmacy, Moga, 142001, Punjab, India

    Urvashi Langeh, Vishal Kumar, Charan Singh & Arti Singh

  2. IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India

    Urvashi Langeh, Vishal Kumar, Charan Singh & Arti Singh

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  1. Urvashi Langeh
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UL wrote the manuscript VK revised the manuscript and CS critically revised the manuscript, and AS verified the manuscript. All authors read and approved the manuscript.

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Correspondence to Arti Singh.

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Langeh, U., Kumar, V., Singh, C. et al. Drug-herb combination therapy in cancer management. Mol Biol Rep 49, 11009–11024 (2022). https://doi.org/10.1007/s11033-022-07861-9

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