Abstract
As shown in the previous studies, hypothyroidism (HT) is identified to be closely associated with the elevated plasma levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and with the decreased plasma levels of high density lipoprotein cholesterol (HDL-C). On the other hand, the thyroid hormone (TH), which has been considered as a vital hormone produced and released by the thyroid gland, are well-established to regulate the metabolism of plasma TC; whereas other evidence proposed that the thyroid-stimulating hormone (TSH) also regulated the plasma cholesterol metabolism independently of the TH, which further promotes the progression of hyperlipidemia. Nevertheless, the potential mechanism is still not illustrated. It is worth noting that several studies has found that the progression of HT-induced hyperlipidemia might be associated with the down-regulated plasma levels of TH and the up-regulated plasma levels of TSH, revealing that HT could promote hyperlipidemia and its related cardio-metabolic disorders. Otherwise, multiple novel identified plasma proteins, such as proprotein convertase subtilisin/kexin type 9 (PCSK9), angiopoietin-like protein (ANGPTLs), and fibroblast growth factors (FGFs), have also been demonstrated to embrace a vital function in modulating the progression of hyperlipidemia induced by HT. In the present comprehensive review, the recent findings which elucidated the association of HT and the progression of hyperlipidemia were summarized. Furthermore, other results which illustrated the underlying mechanisms by which HT facilitates the progression of hyperlipidemia and its cardio-metabolic disorders are also listed in the current review.
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Change history
07 February 2023
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1007/s11033-023-08312-9
Abbreviations
- LDL-C:
-
low-density lipoprotein cholesterol
- VLDL-C:
-
very low-density lipoprotein cholesterol
- TG:
-
triglyceride
- TRL:
-
TG-rich lipoprotein
- NO:
-
nitric oxide
- Apo-B:
-
apolipoprotein B
- CM:
-
chylomicron
- LRP1:
-
low-density lipoprotein receptor related protein 1
- CRP:
-
C-reactive protein
- PCSK9:
-
proprotein convertase subtilisin/kexin type 9
- ANGPTL:
-
angiopoietin-like protein
- FGF:
-
fibroblast growth factor
- RLP:
-
remnant lipoprotein
- THR:
-
thyroid hormones receptor
- T3:
-
triiodothyronine
- SREBP:
-
sterol regulatory element binding protein
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This work was supported by grants from the Xiamen medical and health guiding project (No. 3502Z20214ZD1181 and No. 3502Z20214ZD1174).
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X.S. and X.C. contributed to the study design; X.S. and B.W. wrote the manuscript. All authors reviewed drafts and approved the final version of the manuscript.
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Su, X., Chen, X. & Wang, B. RETRACTED ARTICLE: Relationship between the development of hyperlipidemia in hypothyroidism patients. Mol Biol Rep 49, 11025–11035 (2022). https://doi.org/10.1007/s11033-022-07423-z
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DOI: https://doi.org/10.1007/s11033-022-07423-z