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Genetics of atrial fibrillation—an update of recent findings

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Abstract

Atrial fibrillation (AF) is a common cardiac arrhythmia and a major risk factor for stroke, heart failure, and premature death. AF has a strong genetic predisposition. This review highlights the recent findings on the genetics of AF from genome-wide association studies (GWAS) and high-throughput sequencing studies. The consensus from GWAS implies that AF is both polygenic and pleiotropic in nature. With the advent of whole-genome sequencing and whole-exome sequencing, rare variants associated with AF pathogenesis have been identified. The recent studies have contributed towards better understanding of AF pathogenesis.

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The work was supported by ICMR Project: No.5/4-5/1-6/2020-NCD-II.

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  1. Multi-Disciplinary Center for Biomedical Research, Vinayaka Mission’s Research Foundation, Aarupadai Veedu Medical College and Hospital, Puducherry, 607402, India

    Aarthi Manoharan, Ravikumar Sambandam & Vishnu Bhat Ballambattu

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AM conceptualized, initiated, performed the literature search, and wrote the original draft. RS and VB supervised, reviewed, and revised the review critically for important intellectual content.

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Manoharan, A., Sambandam, R. & Ballambattu, V.B. Genetics of atrial fibrillation—an update of recent findings. Mol Biol Rep 49, 8121–8129 (2022). https://doi.org/10.1007/s11033-022-07420-2

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