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The significance of the SDF-1/CXCR4 signaling pathway in the normal development

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Abstract

Chemokines are chemoattractants that can regulate cell movement and adhesion. SDF-1 [stromal cell-derived factor-1 (SDF-1)] is a homeostatic CXC chemokine. SDF-1 and its receptors [CXC chemokine receptor 4 (CXCR4)] form a signaling pathway that plays critical roles in different pathological and physiological mechanisms, including embryogenesis, wound healing, angiogenesis, tumor growth, and proliferation. Therefore, the current review aimed to summarize the related studies that addressed the molecular signature of the SDF-1/CXCR4 pathway and to explain how this axis is involved in normal events.

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Acknowledgements

This survey was supported by the Birjand University of Medical Sciences.

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No funding was received.

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Authors and Affiliations

  1. Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran

    Farzad Sadri

  2. Department of Biology, University of Sistan and Baluchestan, Zahedan, Iran

    Zohreh Rezaei

  3. Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran

    Zohreh Rezaei & Mohammad Fereidouni

  4. Department of Medical Immunology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran

    Mohammad Fereidouni

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  1. Farzad Sadri
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  2. Zohreh Rezaei
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  3. Mohammad Fereidouni
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All authors have contributed equally to this study.

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Correspondence to Mohammad Fereidouni.

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Farzad Sadri declares that he has no conflict of interest. Zohreh Rezaei declares that she has no conflict of interest. Mohammad Fereidouni declares that he has no conflict of interest.

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Sadri, F., Rezaei, Z. & Fereidouni, M. The significance of the SDF-1/CXCR4 signaling pathway in the normal development. Mol Biol Rep 49, 3307–3320 (2022). https://doi.org/10.1007/s11033-021-07069-3

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  • DOI: https://doi.org/10.1007/s11033-021-07069-3

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