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The association between genetic variants in the genes for cytochrome P450 B1 and ATP-binding cassette transporter genes and breast cancer risk

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Abstract

Breast cancer is among the most common malignancies in women. Recent studies have shown that polymorphisms in genes involved in the metabolism and transport of anticancer drugs are associated with outcomes of several malignancies, e.g., breast cancer. In this study we evaluate whether CYP1B1/rs1056836 and ABCB1/rs2032582 gene variants are associated with breast cancer. Eighty eight cases and 200 controls, were genotyped for polymorphisms of the CYP1B1 and ABCB1 genes using Taqman®-based methods. Logistic regression was also used to test the associations between breast cancer risk and the various genotypes involved. The GG genotype of rs2032582 locus had a frequency of 43.5% with 0.38 MAF; while the GT and TT genotypes in the control group were 40% and 16.5%, respectively. The GG, GT and TT genotype frequencies in the patients with breast cancer were 45.5%, 12.5% and 26.1%, respectively. An association was observed between the TT genotype of ABCB1/rs2032582 locus and a larger breast cancer tumor size (P < 0.05). However, neither the relationship between the CYP1B1 polymorphism and breast cancer type nor the risk of breast cancer were statistically significant. Our data suggest a potential association of the ABCB1 genetic variant with breast cancer tumor size, however further investigation in a larger population is necessary to show its value as a risk stratification biomarker.

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Acknowledgement

We would like to thanks Nastaran Bani, Sajjad Hoseinpour, Majid Ghayour-Mobarhan for their help for improving our manuscript, statistical analysis and providing samples.

Funding

This study was supported by Grants (941296 and 940724) from Mashhad University of Medical Sciences.

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    Authors and Affiliations

    1. Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

      Soodabeh ShahidSales & Davood Radmanesh

    2. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

      Mehrane Mehramiz, Azam Rastgar-Moghadam, Seyed Mahdi Hassanian, Majid Khazaei & Amir Avan

    3. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

      Hamideh Ghazizade & Amir Avan

    4. Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, Sussex, UK

      Gordon A. Ferns

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    1. Soodabeh ShahidSales
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    Soodabeh ShahidSales, Mehrane Mehramiz and Davood Radmanesh have contributed equally as the first author.

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    ShahidSales, S., Mehramiz, M., Radmanesh, D. et al. The association between genetic variants in the genes for cytochrome P450 B1 and ATP-binding cassette transporter genes and breast cancer risk. Mol Biol Rep 47, 6009–6014 (2020). https://doi.org/10.1007/s11033-020-05674-2

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