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Molecular dynamics simulation as a tool for assessment of drug binding property of human serum albumin

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Abstract

Human serum albumin (HSA) is a major plasma protein and binding of drugs with this plasma protein has a great importance. It possess esterase activity which can cleave the drugs containing ester bond and thus, can regulate the effect of drugs. Till date no systematic study has been done to analyse binding of such drugs and to compare the results with the drugs which do not have ester bond. Therefore, in the present study two different categories—ester and non-ester drugs have been considered to analyse their interaction with HSA at two principle drug binding sites using molecular modelling tools. It is observed that the drugs irrespective of ester or non-ester nature prefer either Sudlow site I or II by hydrogen bond and hydrophobic interactions. The information obtained from the study can assist to study pharmacokinetics of the drugs and that in turn will help in noval drug discoveries.

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Abbreviations

HSA:

Human serum albumin

MD:

Molecular dynamics

Rg:

Radius of gyration

RMSD:

Root mean square deviation

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Acknowledgements

DK acknowledges Council of Scientific and Industrial Research, India for providing fellowship (File No: 09/141(0197)/2016-EMR-I).

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Authors and Affiliations

  1. Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, Haryana, 133203, India

    Meenu Narwal & Tapan Kumar Mukherjee

  2. Department of Experimental Medicine and Biotechnology, PGIMER, Chandigarh, 160012, India

    Deepak Kumar, Rajasri Bhattacharyya & Dibyajyoti Banerjee

Authors
  1. Meenu Narwal
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  2. Deepak Kumar
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  3. Tapan Kumar Mukherjee
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  4. Rajasri Bhattacharyya
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  5. Dibyajyoti Banerjee
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Correspondence to Rajasri Bhattacharyya or Dibyajyoti Banerjee.

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Narwal, M., Kumar, D., Mukherjee, T.K. et al. Molecular dynamics simulation as a tool for assessment of drug binding property of human serum albumin. Mol Biol Rep 45, 1647–1652 (2018). https://doi.org/10.1007/s11033-018-4308-3

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  • DOI: https://doi.org/10.1007/s11033-018-4308-3

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