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Polymorphisms in interleukins 17A and 17F genes and periodontitis: results from a meta-analysis

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Abstract

Polymorphisms in inflammatory genes such as interleukins 17A and 17F are associated with the risk of development of periodontitis, although the results remain contradictory. Hence, the aim of this study was perform a meta-analysis focusing on two polymorphisms (rs2275913 and rs763780) in interleukins 17A and 17F genes, respectively, in both chronic (CP) and aggressive periodontitis (AgP). A review in literature was performed in several databases for studies published before 25, September 2016. The meta-analysis was obtained through the review manager statistical software (version 5.2) with odds ratio (OR) calculation and funnel plot (P < 0.05) for heterogeneity, as well as the comprehensive meta-analysis software (version 3.3.070) for the assessment of publication bias. Seven articles with 1540 participants composed the results in which the mutant allele in the rs2275913 polymorphism did not present significant association with the risk of CP or AgP (OR 1.56, 95% CI 0.77, 3.15, P = 0.21; OR 1.12, 95% CI 0.05, 23.44, P = 0.94, respectively) nor was the mutant allele in rs763780 associated with the risk of CP (OR 1.19, 95% CI 0.80, 1.76, P = 0.39) or AgP (OR 1.07, 95% CI 0.63, 1.84, P = 0.79). No bias of publication was observed by Egger’s and Begg’s tests in any allelic evaluation. This meta-analysis showed a non-significant association between the polymorphisms rs2275913 and rs763780 in interleukins 17A and 17F genes and chronic and aggressive periodontitis in the allelic evaluation.

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Acknowledgements

Federal University of Piaui supported this study (UFPI—Edital PIBIC 2014/2015; Edital PIBIC 2015/2016), CNPq (455104/2014-0) and CAPES by FRPS. We thank teacher Abílio Borghi for the grammar review of the article.

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Authors and Affiliations

  1. Laboratory of Histological Analysis and Preparation (LAPHIS), Federal University of Piaui, Parnaiba, PI, Brazil

    Felipe Rodolfo Pereira da Silva, Larissa dos Santos Pessoa, Any Carolina Cardoso Guimarães Vasconcelos, Even Herlany Pereira Alves & Daniel Fernando Pereira Vasconcelos

  2. Medicine School, Education Institute of Parnaiba Valley (IESVAP), Parnaiba, PI, Brazil

    Any Carolina Cardoso Guimarães Vasconcelos

  3. Federal University of Rio Grande do Norte, Currais Novos, RN, Brazil

    Weberson de Aquino Lima

  4. Universidade Federal do Piauí – UFPI, Campus Ministro Reis Veloso, Colegiado de Biomedicina, Av. São Sebastião, 2819, Reis Veloso, Parnaiba, PI, 64204-035, Brazil

    Daniel Fernando Pereira Vasconcelos

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FRPS, ACCGV, WAL and DFPV contributed in the conception, design, data collection, statistical analysis and drafting of the manuscript. LSP, EHPA contributed in the data collection, statistical analysis and review of the manuscript. All authors approved the final version for submission.

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Correspondence to Daniel Fernando Pereira Vasconcelos.

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da Silva, F.R.P., Pessoa, L.d.S., Vasconcelos, A.C.C.G. et al. Polymorphisms in interleukins 17A and 17F genes and periodontitis: results from a meta-analysis. Mol Biol Rep 44, 443–453 (2017). https://doi.org/10.1007/s11033-017-4128-x

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