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A versatile approach for one-pot synthesis of hybridized quinolines linked to fused N-containing heterocycles in water

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Abstract

Here, highly efficient one-pot protocols for the synthesis of structurally diverse fused N-containing heterocycles containing 2-chloroquinoline employing 1,1-bis(methylsulfanyl)-2-nitroethene, diamines, 2-chloroquinoline-3-carbaldehydes and dimedone/Meldrum's acid in green media in the absence of catalyst are reported. The current report proposes sustainable, simple, four-component and straightforward strategies for generating interesting N-containing heterocyclic compounds from a range of diamines and 2-chloroquinoline-3-carbaldehydes. The utilization of water as green media furnishes sustainability by preventing the usage of toxic solvent. A range of quinoline-containing aldehydes and diamines can be converted to two types of products with respect to using dimedone or Meldrum's acid via an inexpensive, one-pot and easy route.

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Acknowledgements

Financial support from the Research Council of Alzahra University is sincerely acknowledged.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Chemistry, Alzahra University, Tehran, Iran

    Atieh Rezvanian, Behnoosh Khodadadi & Sepideh Tafreshi

  2. Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

    Pezhman Shiri

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  1. Atieh Rezvanian
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AR, BK and ST worked in experimental section, and analyzed spectral characterization of synthesized molecules. AR and PS wrote and edited the article.

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Correspondence to Atieh Rezvanian.

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Rezvanian, A., Khodadadi, B., Tafreshi, S. et al. A versatile approach for one-pot synthesis of hybridized quinolines linked to fused N-containing heterocycles in water. Mol Divers 28, 197–207 (2024). https://doi.org/10.1007/s11030-023-10719-2

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