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Catalyst-free synthesis of acenaphthoindolopyrimidine derivatives

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Abstract

A one pot three component reaction of acenaphthoquinone, barbituric acid/thiobarbituric acid/N,N-dimethyl barbituric acid and arylamines in ethanol for the synthesis of acenaphthoindolopyrimidine derivatives is reported. The reactions take place without a catalyst and gentle conditions. This method is facile and has some benefits such as, readily available starting materials, green solvent, catalyst-free, no column chromatographic purification and good to high yields.

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Acknowledgements

Financial support of this research from Imam Khomeini International University, Iran is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Imam Khomeini International University, Qazvin, Iran

    Nahale Kakavand & Mohammad Bayat

  2. Department of Chemistry and Chemical Engineering, Malek Ashtar University of Technology, Tehran, Iran

    Yadollah Bayat

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  1. Nahale Kakavand
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  2. Mohammad Bayat
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Correspondence to Mohammad Bayat.

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Kakavand, N., Bayat, M. & Bayat, Y. Catalyst-free synthesis of acenaphthoindolopyrimidine derivatives. Mol Divers 27, 1785–1793 (2023). https://doi.org/10.1007/s11030-022-10531-4

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  • DOI: https://doi.org/10.1007/s11030-022-10531-4

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