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5-Endo-dig cyclizations in organic syntheses

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Abstract

The favorability of ring closure reactions as per Baldwin rules has gained immense importance recently. This is evident from the current literature such as research articles, reviews, and books that have been published in this area. This review covers the recent applications of 5-endo-dig cyclization in organic synthesis focusing in the last two decades. A variety of 5-membered heterocycles as well as carbocycles could be synthesized via 5-endo-dig cyclization reactions. The important applications of 5-endo-dig cyclization in organic synthesis covering different aspects have been summarized in this review.

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Acknowledgements

The second and third authors are grateful to Professor Dr. Thomas Wirth, Cardiff University, UK, for proof reading and valuable suggestions to improve the manuscript. The corresponding author is grateful to Higher Education Commission, Pakistan (Project No. PM-IPFP/HRD/HEC/2011/2063) and Government College University, Faisalabad (GCUF-RSP Project No. 61-CHM-1) for providing the facilities to carry out this work.

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  1. Department of Chemistry, Faculty of Physical Sciences, Government College University, Faisalabad, 38000, Pakistan

    Muhammad Aamir Sajid, Zulfiqar Ali Khan, Syed Ali Raza Naqvi & Muhammad Usman

  2. Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, 22060, Pakistan

    Sohail Anjum Shahzad

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Sajid, M.A., Khan, Z.A., Shahzad, S.A. et al. 5-Endo-dig cyclizations in organic syntheses. Mol Divers 24, 295–317 (2020). https://doi.org/10.1007/s11030-019-09930-x

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