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DBU-catalyzed, aromatization-oriented, regioselective domino synthesis of 2-aminopyrimidines from \(\upbeta \)-dicarbonyl compounds, DMF-DMA, and cyanamide

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Abstract

A multicomponent domino synthesis has been developed for the preparation of 2-aminopyrimidines from \(\upbeta \)-dicarbonyl compounds, N,N-dimethylformamide dimethyl acetal, and cyanamide. The protocol was used for the regioselective preparation of 4-amide/ester/ketone substituted 2-aminopyrimidines. Twelve 2-aminopyrimidines were isolated in good yields (56–93%).

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Acknowledgements

This study was financially supported by The Scientific and Technological Research Council of Turkey (TÜBİTAK), Project No. 115Z448.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Art and Science, Bozok University, 66200, Atatürk Yolu, Yozgat, Turkey

    Şevket Hakan Üngören & Şerife Boz

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  1. Şevket Hakan Üngören
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  2. Şerife Boz
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Correspondence to Şevket Hakan Üngören.

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Üngören, Ş.H., Boz, Ş. DBU-catalyzed, aromatization-oriented, regioselective domino synthesis of 2-aminopyrimidines from \(\upbeta \)-dicarbonyl compounds, DMF-DMA, and cyanamide. Mol Divers 21, 925–932 (2017). https://doi.org/10.1007/s11030-017-9770-7

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