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RhoA/ROCK signaling pathway and astrocytes in ischemic stroke

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Abstract

Ischemic stroke is one of the most common and undertreated cerebral diseases with high mortality and disability rate. Various intrinsic and extrinsic factors regulate the onset, severity, and progression of ischemic stroke. As an integral part of the neuronal glia system, astrocytes provide many housekeeping functions in nervous system, and perform multiple functions both beneficial and detrimental for neuronal survival after ischemic stroke. In addition, the small GTPase Rho and its downstream Rho kinase (ROCK) are associated with various neuronal functions such as dendrite development, migration and axonal extension, and numerous central nervous system (CNS) diseases. The aim of this review is to summarize the role of RhoA/ROCK signaling pathway and astrocytes on neurological function after ischemic stroke. We also discuss the interaction of RhoA/ROCK signaling pathway and astrocytes on the tissue repair after brain injury.

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This study was funded by grants for teaching and research project of Hefei Technology College (No. 2019JYXM022).

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  1. Medical School, Hefei Technology College, Hefei, China

    Weizhuo Lu

  2. Department of Pharmacology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China

    Zhiwu Chen & Jiyue Wen

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Lu WZ and Wen JY: Participated in writing of the manuscript; Chen ZW: Participated in review design.

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Lu, W., Chen, Z. & Wen, J. RhoA/ROCK signaling pathway and astrocytes in ischemic stroke. Metab Brain Dis 36, 1101–1108 (2021). https://doi.org/10.1007/s11011-021-00709-4

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