Abstract
Amyotrophic lateral sclerosis (ALS) is a deadly motor neuron disease (MND) and the most frequent MND in adults. ALS is recognized by degenerative alterations in both upper and lower motor neurons. This disorder is classified to familial and sporadic classes. Disease-causing mutations in SOD1, C9ORF72, FUS, and TARDBP have been recognized in familial ALS cases. However, in spite of conduction of several genetic association studies, heritable genetic risk elements in sporadic have not been identified completely. Several miRNAs have been dysregulated in the serum samples or brain tissues of ALS patients. Moreover, a number of miRNAs have been suggested as putative biomarkers for sporadic ALS. In the current manuscript, we review of miRNAs in the development of ALS.
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This study was financially supported by Shahid Beheshti University of Medical Sciences.
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MT and SGF wrote the draft and revised it. NAD, SN and BMH collected the data, designed the tables and figures. All the authors contribute equally and read the submission.
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Akbari Dilmaghani, N., Hussen, B.M., Nateghinia, S. et al. Emerging role of microRNAs in the pathogenesis of amyotrophic lateral sclerosis. Metab Brain Dis 36, 737–749 (2021). https://doi.org/10.1007/s11011-021-00697-5
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DOI: https://doi.org/10.1007/s11011-021-00697-5