Abstract
The aim of this study was to investigate the influence of Bisphenol A (BPA) exposure on Neuroglobin (Ngb) and Cytoglobin (Cygb) as well as oxidative stress gene expression in the cerebellum, hippocampus, hypothalamus and cortex. Male Wistar rats were randomly divided into 3 groups: Control and two groups receiving 2 different daily BPA dosages, 5 or 25 mg/kg from postnatal day 50 (PND50) through PND90 and they were euthanized at PND105. In the cortex, we found an increase in Ngb gene expression and also in superoxide dismutase 1 and Catalase (Cat). In the cerebellum, we found an increase in Ngb and Cat, in the hypothalamus, there was a decrease in Cygb and an increase in glutathione peroxidase and Cat and in hypoxia-inducible factor 1 alpha (Hif1α) at the low dosage and a decrease in Hif1α at the high BPA dosage. Finally, in the hippocampus, we observed a decrease in Ngb and Cygb and an increase in Hif1α. In summary, BPA promotes the modulation of both Ngb and Cygb, but such changes occur by different mechanisms depending on the exposure dose and anatomical area.
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20 September 2017
An erratum to this article has been published.
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Acknowledgements
The authors are grateful for the financial support of Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES; 18952-12-7) to J. Sena-Souza. Ted Buras and Glenn C. Johnston for English revision.
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This project was funded by Coordenação de Aperfeiçoamento de pessoal de nível superior (CAPES, process number 18952–12-7) to JSS, Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, process number 2013/26851–7) to MIC and CAPES – AUXPE Pró-integração process number 3160/2013–98) to MRDS.
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The original version of this article was revised: The author name Maria Izabel Chiamolera was incorrectly listed as Maria Izabel Chiamorela.
An erratum to this article is available at https://doi.org/10.1007/s11011-017-0112-3.
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da Conceição, R.R., de Souza, J.S., de Oliveira, K.C. et al. Anatomical specificity of the brain in the modulation of Neuroglobin and Cytoglobin genes after chronic bisphenol a exposure. Metab Brain Dis 32, 1843–1851 (2017). https://doi.org/10.1007/s11011-017-0066-5
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DOI: https://doi.org/10.1007/s11011-017-0066-5