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Histomorphology of Seminal Vesicles Subsequent to Exogenous Neurokinin B Administration in New Zealand White Rabbits

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Abstract

Neurokinin B exists as a member of tachykinin family, which is encoded by Tac3 gene and binds to Tac3R. Several studies have shown that neurokinin B is involved in secretion of gonadotropin releasing hormone and maintenance of reproductive function. No data on the effect of neurokinin B on accessory sex glands is available till date. The current study is designed to determine the dose dependent effects of neurokinin B on seminal vesicles of New Zealand White Rabbits. For experimental procedure, 18 New Zealand white rabbits (Oryctolagus cuniculus) were purchased from National Institute Health, Islamabad Pakistan. Adult laboratory rabbits were administrated with neurokinin B at two different dose concentrations (1 ηg and 1 µg) twice daily for a period of continuous 12 days. The results demonstrated a significant increase in seminal vesicles weight and epithelial cell height at all tested doses (P < 0.05). Marked increase in epithelial folds was readily manifested, however the lumen was irregular. In this study histological and structural alterations in seminal vesicles manifest a progressive effect on seminal vesicles subsequent to subcutaneous twice-daily administration of Neurokinin B for 12 days.

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Acknowledgements

The authors are grateful to Mr. Zubair, Senior Technician, Gomal Medical College, Dera Ismail Khan for his help in tissue sectioning. The authors are thankful to Miss Maria Wishal for providing assistance in statistical analysis.

Funding

The present study did not get any financial assistance.

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Authors and Affiliations

  1. Animal Biotechnology Laboratory, Gomal Centre of Biochemistry and Biotechnology, Gomal University, Dera Ismail Khan, 29050, Pakistan

    Zain Ullah & Faiqah Ramzan

  2. Department of Physiology, Khyber Medical University Institute of Medical Sciences (KMU-IMS), Kohat, 26000, Pakistan

    Muhammad Haris Ramzan

  3. Laboratory of Neuroendocrinology, Department of Animal and Poultry Production, Faculty of Veterinary and Animal Sciences, Gomal University, Dera Ismail Khan, 29050, Pakistan

    Faiqah Ramzan

Authors
  1. Zain Ullah
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  2. Muhammad Haris Ramzan
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Contributions

ZU conducted the experiments. Concept & study design, analysis & interpretation of data of data was executed by FR, MHR executed the experiments, drafted the manuscript.

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Correspondence to Faiqah Ramzan.

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Ullah, Z., Ramzan, M.H. & Ramzan, F. Histomorphology of Seminal Vesicles Subsequent to Exogenous Neurokinin B Administration in New Zealand White Rabbits. Int J Pept Res Ther 26, 2021–2027 (2020). https://doi.org/10.1007/s10989-019-10001-w

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  • DOI: https://doi.org/10.1007/s10989-019-10001-w

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