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Thermal expansivity and degradation properties of PLA/HA and PLA/βTCP in vitro conditioned composites

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Abstract

The objective of this study was to investigate the thermal expansivities and degradation properties for several in vitro conditioned biodegradable poly(lactic acid)/hydroxyapatite (PLA/HA) and poly(lactic acid)/β-tricalcium phosphate (PLA/βTCP) composites with different mass% of the particle reinforcements (i.e. 10, 20 and 30). The samples were prepared by extrusion followed by injection moulding and incubated in a customized simulated body fluid at 37 °C over 60, 90, 120, 150 and 180 days, respectively. Thermal expansion and degradation properties of in vitro conditioned samples, along with dynamic mechanical properties of unconditioned ones, were systematically investigated through coefficients of linear thermal expansion and thermal strain changes, decomposition temperatures, mass changes and per cent residues. The results indicated that PLA/βTCP composites performed better than PLA/HA composites, irrespective of their filler mass%, revealing high values of glass transition temperatures, around a mean value of 65 °C, both on dynamic mechanical analysis and on dilatation measurements but lower values on their degradation temperatures, such as 360 °C. The results suggest the feasibility of tailoring high-loaded osteoconductive fillers-reinforced PLA composites for various medical and engineering applications.

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References

  1. Auras R, Lim LT, Selke S, Tsuji H. Poly(lactic acid): structures, production, synthesis, and applications. New York: Wiley; 2010.

    Book  Google Scholar 

  2. Murariu M, Dubois P. PLA composites: from production to properties. Adv Drug Deliv Rev. 2016;107:17–46.

    Article  CAS  Google Scholar 

  3. Haaparanta A-M, Haimi S, Ellä V, Hopper N, Miettinen S, Suuronen R, et al. Porous polylactide/β-tricalcium phosphate composite scaffolds for tissue engineering applications. J Tissue Eng Regen Med. 2010;4(5):366–73.

    Article  CAS  Google Scholar 

  4. Ahmed J, Varshney SK. Polylactides—chemistry, properties and green packaging technology: a review. Int J Food Prop. 2011;14(1):37–58.

    Article  CAS  Google Scholar 

  5. Garlotta D. A literature review of poly(lactic acid). J Polym Environ. 2001;9(2):63–84.

    Article  CAS  Google Scholar 

  6. Slomkowski S, Penczek S, Duda A. Polylactides—an overview. Polym Adv Technol. 2014;25(5):436–47.

    Article  CAS  Google Scholar 

  7. Avinc O, Khoddami A. Overview of poly(lactic acid) (PLA) fibre. Fibre Chem. 2009;41(6):391–401.

    Article  CAS  Google Scholar 

  8. Akindoyo JO, Beg MDH, Ghazali S, Heim HP, Feldmann M. Impact modified PLA-hydroxyapatite composites—thermo-mechanical properties. Compos A Appl Sci Manuf. 2018;107:326–33.

    Article  CAS  Google Scholar 

  9. Nazhat SN, Kellomäki M, Törmälä P, Tanner KE, Bonfield W. Dynamic mechanical characterization of biodegradable composites of hydroxyapatite and polylactides. J Biomed Mater Res. 2001;58(4):335–43.

    Article  CAS  Google Scholar 

  10. Ignjatovic N, Uskokovic D. Synthesis and application of hydroxyapatite/polylactide composite biomaterial. Appl Surf Sci. 2004;238(1):314–9.

    Article  CAS  Google Scholar 

  11. Li J, Zheng W, Li L, Zheng Y, Lou X. Thermal degradation kinetics of g-HA/PLA composite. Thermochim Acta. 2009;493(1):90–5.

    Article  CAS  Google Scholar 

  12. Zhang SM, Liu J, Zhou W, Cheng L, Guo XD. Interfacial fabrication and property of hydroxyapatite/polylactide resorbable bone fixation composites. Curr Appl Phys. 2005;5(5):516–8.

    Article  Google Scholar 

  13. Akindoyo JO, Beg MDH, Ghazali S, Heim HP, Feldmann M. Effects of surface modification on dispersion, mechanical, thermal and dynamic mechanical properties of injection molded PLA-hydroxyapatite composites. Compos A Appl Sci Manuf. 2017;103:96–105.

    Article  CAS  Google Scholar 

  14. Kang Y, Yao Y, Yin G, Huang Z, Liao X, Xu X, et al. A study on the in vitro degradation properties of poly(l-lactic acid)/β-tricalcuim phosphate(PLLA/β-TCP) scaffold under dynamic loading. Med Eng Phys. 2009;31(5):589–94.

    Article  Google Scholar 

  15. Huang J, Ten E, Liu G, Finzen M, Yu W, Lee JS, et al. Biocomposites of pHEMA with HA/β-TCP (60/40) for bone tissue engineering: swelling, hydrolytic degradation, and in vitro behavior. Polymer. 2013;54(3):1197–207.

    Article  CAS  Google Scholar 

  16. Bleach NC, Nazhat SN, Tanner KE, Kellomäki M, Törmälä P. Effect of filler content on mechanical and dynamic mechanical properties of particulate biphasic calcium phosphate—polylactide composites. Biomaterials. 2002;23(7):1579–85.

    Article  CAS  Google Scholar 

  17. Ferri J, Gisbert I, García-Sanoguera D, Reig M, Balart R. The effect of beta-tricalcium phosphate on mechanical and thermal performances of poly(lactic acid). J Compos Mater. 2016;50(30):4189–98.

    Article  CAS  Google Scholar 

  18. Li X, Qi C, Han L, Chu C, Bai J, Guo C, et al. Influence of dynamic compressive loading on the in vitro degradation behavior of pure PLA and Mg/PLA composite. Acta Biomater. 2017;64:269–78.

    Article  CAS  Google Scholar 

  19. Agrawal CM, McKinney JS, Lanctot D, Athanasiou KA. Effects of fluid flow on the in vitro degradation kinetics of biodegradable scaffolds for tissue engineering. Biomaterials. 2000;21(23):2443–52.

    Article  CAS  Google Scholar 

  20. Kikuchi M, Koyama Y, Takakuda K, Miyairi H, Shirahama N, Tanaka J. In vitro change in mechanical strength of β-tricalcium phosphate/copolymerized poly-L-lactide composites and their application for guided bone regeneration. J Biomed Mater Res. 2002;62(2):265–72.

    Article  CAS  Google Scholar 

  21. Lim LT, Auras R, Rubino M. Processing technologies for poly(lactic acid). Prog Polym Sci. 2008;33(8):820–52.

    Article  CAS  Google Scholar 

  22. Ignjatovic N, Suljovrujic E, Budinski-Simendic J, Krakovsky I, Uskokovic D. Evaluation of hot-pressed hydroxyapatite/poly-L-lactide composite biomaterial characteristics. J Biomed Mater Res B Appl Biomater. 2004;71B(2):284–94.

    Article  CAS  Google Scholar 

  23. Martin C. Twin screw extrusion for pharmaceutical processes. In: Repka MA, Langley N, DiNunzio J, editors. Melt extrusion: materials, technology and drug product design. New York: Springer; 2013. p. 47–79.

    Chapter  Google Scholar 

  24. Cox SC, Thornby JA, Gibbons GJ, Williams MA, Mallick KK. 3D printing of porous hydroxyapatite scaffolds intended for use in bone tissue engineering applications. Mater Sci Eng C. 2015;47:237–47.

    Article  CAS  Google Scholar 

  25. Corcione C, Scalera F, Gervaso F, Montagna F, Sannino A, Maffezzoli A. One-step solvent-free process for the fabrication of high loaded PLA/HA composite filament for 3D printing. J Therm Anal Calorim. 2018;134:1–8.

    Article  CAS  Google Scholar 

  26. Siqueira L, Passador FR, Costa MM, Lobo AO, Sousa E. Influence of the addition of β-TCP on the morphology, thermal properties and cell viability of poly (lactic acid) fibers obtained by electrospinning. Mater Sci Eng C. 2015;52:135–43.

    Article  CAS  Google Scholar 

  27. Drummer D, Cifuentes-Cuéllar S, Rietzel D. Suitability of PLA/TCP for fused deposition modeling. Rapid Prototyp J. 2012;18(6):500–7.

    Article  Google Scholar 

  28. Ferri J, Jordá J, Montanes N, Fenollar O, Balart R. Manufacturing and characterization of poly(lactic acid) composites with hydroxyapatite. J Thermoplast Compos Mater. 2018;31(7):865–81.

    Article  CAS  Google Scholar 

  29. Ferri J, Jordá J, Montanes N, Fenollar O, Balart R. Manufacturing and characterization of poly(lactic acid) composites with hydroxyapatite. J Thermoplast Compos Mater. 2018;31(7):865–81.

    Article  CAS  Google Scholar 

  30. Menczel JD, Prime RB. Thermal analysis of polymers: fundamentals and applications. New York: Wiley; 2014.

    Google Scholar 

  31. Aboudi J, Arnold SM, Bednarcyk BA. Chapter 3—fundamentals of the mechanics of multiphase materials. In: Aboudi J, Arnold SM, Bednarcyk BA, editors. Micromechanics of composite materials. Oxford: Butterworth-Heinemann; 2013. p. 87–145.

    Chapter  Google Scholar 

  32. Esposito Corcione C, Gervaso F, Scalera F, Padmanabhan SK, Madaghiele M, Montagna F, et al. Highly loaded hydroxyapatite microsphere/PLA porous scaffolds obtained by fused deposition modelling. Ceram Int. 2018;45:2803–10.

    Article  CAS  Google Scholar 

  33. Zou H, Yi C, Wang L, Liu H, Xu W. Thermal degradation of poly(lactic acid) measured by thermogravimetry coupled to Fourier transform infrared spectroscopy. J Therm Anal Calorim. 2009;97(3):929.

    Article  CAS  Google Scholar 

  34. Schindler A, Doedt M, Gezgin Ş, Menzel J, Schmölzer S. Identification of polymers by means of DSC, TG, STA and computer-assisted database search. J Therm Anal Calorim. 2017;129(2):833–42.

    Article  CAS  Google Scholar 

  35. Lee WA, Knight GJ. Ratio of the glass transition temperature to the melting point in polymers. Br Polym J. 1970;2(1):73–80.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Mechanical and Materials Engineering, Universitat Politècnica de València, Plaza Ferrandiz y Carbonell, s/n, Alcoy, Alicante, Spain

    J. M. Ferri, S. Ferrandiz Bou & R. Balart

  2. Department of Automotive and Transport Engineering, Transilvania University of Brasov, Eroilor Av., 500036, Brasov, Romania

    D. Luca Motoc

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Correspondence to D. Luca Motoc.

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Ferri, J.M., Motoc, D.L., Bou, S.F. et al. Thermal expansivity and degradation properties of PLA/HA and PLA/βTCP in vitro conditioned composites. J Therm Anal Calorim 138, 2691–2702 (2019). https://doi.org/10.1007/s10973-019-08799-0

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  • DOI: https://doi.org/10.1007/s10973-019-08799-0

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