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Evaluation of thermal stability and kinetic of degradation for levodopa in non-isothermal conditions

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Abstract

In this paper, we present the results obtained during the investigation of thermal stability of antiparkinsonian drug Levodopa in oxidative atmosphere and under non-isothermal conditions. As investigational tools, thermoanalytical methods were used along with ATR-FTIR spectroscopy and later completed with kinetic study for the main degradative process that occurs in the 260–330 °C temperature range, at four heating rates. Four kinetic methods were used as follows: ASTM E698 which leads to an activation energy of 209.72 kJ mol−1, while isoconversional methods suggested the values 177.6 ± 13.1 kJ mol−1 (Friedman) and 188.8 ± 4.5 kJ mol−1 (Kissinger–Akahira–Sunose), with a clear indication of multistep degradation. The last method used was NPK, which revealed that the degradation occurs in three steps, with different physical and chemical contributions with mean activation energy equal to 191.3 ± 9.5 kJ mol−1.

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Abbreviations

A :

Pre-exponential factor (s−1)

E :

Activation energy (kJ mol−1)

R :

Universal gas constant (8.314 J mol−1 K−1)

t :

Time (s)

T :

Temperature (°C or K)

f(α):

Differential form of kinetic mechanism function

g(α):

Integral form of kinetic mechanism function

α :

Conversion degree

β :

Heating rate (°C min−1)

k(T):

Rate constant

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Acknowledgements

This work was supported by the PN-II-RU-TE-2014-4-0515 to Adriana Ledeti, Gabriela Vlase, Denisa Circioban, and Ionut Ledeti.

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Author notes

  1. Adriana Ledeti, Tudor Olariu, and Angelica Caunii contributed equally to this work.

Authors and Affiliations

  1. Faculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041, Timisoara, Romania

    Adriana Ledeti, Tudor Olariu, Angelica Caunii, Gabriela Vlase, Denisa Circioban, Bianca Baul & Ionut Ledeti

  2. Research Center for Thermal Analysis in Environmental Problems, Faculty of Chemistry-Biology-Geography, West University of Timisoara, Pestalozzi Street 16, 300115, Timisoara, Romania

    Denisa Circioban & Titus Vlase

  3. Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041, Timisoara, Romania

    Marius Murariu

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  1. Adriana Ledeti
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Correspondence to Ionut Ledeti.

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Ledeti, A., Olariu, T., Caunii, A. et al. Evaluation of thermal stability and kinetic of degradation for levodopa in non-isothermal conditions. J Therm Anal Calorim 131, 1881–1888 (2018). https://doi.org/10.1007/s10973-017-6671-z

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