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New complexes with 19-membered pyridine-based macrocycle ligand

Synthesis, characterization, thermal and in vitro anticancer activity

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Abstract

A novel series of transition metal complexes with 19-membered pyridine-based macrocycle ligand [L], i.e., 1,5,12,16-tetraaza-3,4:7,10:13,14-tribenzo1,16(2,6-pyrido)cyclononadecan-5,11 diene 2,15 dione, has been isolated and characterized. The mode of bonding and overall geometry of the complexes has been inferred through elemental analysis, spectral, thermal as well as magnetic and molar conductivity measurements. On basis of IR, MS, UV–Vis and EPR spectral studies, an octahedral geometry has been proposed for all complexes except Co(II) chloride and acetate and Cu(II) nitrate complexes that adopt tetrahedral or square planar geometry, respectively. The complexes were also screened for its in vitro anticancer activity against the breast cell line (MFC7) and human hepatocarcinoma cell line (HepG2); the results obtained show that they exhibit potent antitumor activity.

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Acknowledgements

The authors would like to thank Dr. Mahmoud Moawad Lecturer at the National Cancer Institute, Cairo University, Egypt, for his help with the in vitro anticancer activity.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Menoufia University, Shebin El- Kom, Egypt

    Hanaa A. El-Boraey, Azza A. Serag El-Din & Ibrahim El Sayed

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  1. Hanaa A. El-Boraey
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  2. Azza A. Serag El-Din
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  3. Ibrahim El Sayed
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Correspondence to Hanaa A. El-Boraey.

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El-Boraey, H.A., El-Din, A.A.S. & El Sayed, I. New complexes with 19-membered pyridine-based macrocycle ligand. J Therm Anal Calorim 129, 1243–1253 (2017). https://doi.org/10.1007/s10973-017-6169-8

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