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Thermal characterization study of chondroitin sulfate-co-N-isopropylacrylamide as drugs carrier

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Abstract

Poly(N-isopropylacrylamide) (PNIPAAm) is formed by polymerization of the monomer N-isopropylacrylamide (NIPAAm) and is classified as thermosensitive due to its ability to expand and contract at a certain temperature. Chondroitin sulfate is called bioadhesive as it increases the permanence time of the drug in the body, enhancing its bioavailability. In this study, the copolymer chondroitin sulfate-co-N-isopropylacrylamide (CSM) is proposed as a new drug carrier and thermal analysis is used to choose among the copolymers CSM + NIPAAm 5 % (w/v), CSM + NIPAAm 2.5 % (w/v) and CSM + PNIPAAm 2.5 % (w/v), the one with best thermal properties. Proton nuclear magnetic resonance spectroscopy showed structural similarity between the copolymers. Thermogravimetric analysis/derivative thermogravimetry showed that the copolymer CSM + NIPAAm 5 % (w/v) has higher thermal stability when compared to the others. Differential thermal analysis showed thermal values consistent with the events of decomposition while kinetics of degradation confirmed its thermal stability. So the copolymer CSM + NIPAAm 5 % (w/v) presented the best thermal characteristics for an efficient drug carrier.

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Acknowledgements

The authors thank CNPq, PROPESP/UFPA and FADESP for the financial support, EMBRAPA Amazônia Oriental, Faculty of Chemistry and Laboratory of Quality Control and Toxicology, which are part of the Faculty of Pharmacy, Federal University of Pará for their assistance in the experimental stage.

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Authors and Affiliations

  1. Post-Graduate Program in Pharmaceutical Sciences, Federal University of Pará, Augusto Corrêa Street, 01– Guamá, Belém, Pará, 66075-110, Brazil

    Suellen Christtine da Costa Sanches, Flávio de Vasconcelos, José Otávio Carréra Silva Júnior & Roseane Maria Ribeiro-Costa

  2. Post-Graduate Program in Chemistry, Federal University of Pará, Belém, Pará, 66075-110, Brazil

    Carlos Emmerson Ferreira da Costa & Patrícia Santana Barbosa Marinho

  3. Brazilian Agricultural Research Corporation, Belém, Pará, 66095-100, Brazil

    Marcos R. Guilherme & Eraldo José Madureira Tavares

  4. Evandro Chagas Institute, Belém, Pará, 67030-00, Brazil

    José Antônio Picanço Diniz Júnior

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  1. Suellen Christtine da Costa Sanches
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  2. Flávio de Vasconcelos
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Correspondence to Roseane Maria Ribeiro-Costa.

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da Costa Sanches, S.C., de Vasconcelos, F., da Costa, C.E.F. et al. Thermal characterization study of chondroitin sulfate-co-N-isopropylacrylamide as drugs carrier. J Therm Anal Calorim 120, 991–999 (2015). https://doi.org/10.1007/s10973-014-4380-4

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