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Thermal analysis of clathrates of tripeptide LLL with organic compounds and water

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Abstract

Clathrates of l-leucyl-l-leucyl-l-leucine tripeptide (LLL) formed in a solid host/guest vapor system have been studied using X-ray powder diffraction and by simultaneous thermogravimetry and differential scanning calorimetry, combined with mass-spectrometric detection of the evolved vapors. A decrease in the thermal stability of the clathrates was observed as the molecular size of bound organic guests increased. Powdered LLL clathrates with pyridine, and unusually benzene, were found to have a higher thermal stability than expected. However, thin films of the tripeptide clathrate LLL with pyridine were less stable at room temperature. These results can be used to predict the thermal stability of clathrates of short-chain oligopeptides with organic compounds.

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Acknowledgements

This study was supported by the Russian Foundation for Basic Research, Project No. 12-03-00590-a and Russian Government Program of Competitive Growth of Kazan Federal University. The equipment of Federal Center of Shared Equipment FCKP FChI of Kazan Federal University was used in this work.

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Authors and Affiliations

  1. A.M. Butlerov Institute of Chemistry, Kazan Federal University, Kremlevskaya 18, 420008, Kazan, Russia

    Marat A. Ziganshin, Alexander V. Gerasimov & Valery V. Gorbatchuk

  2. A.E. Arbuzov Institute of Organic and Physical Chemistry, Akad. Arbuzova, 8, 420088, Kazan, Russia

    Aidar T. Gubaidullin

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  1. Marat A. Ziganshin
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  2. Alexander V. Gerasimov
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Correspondence to Marat A. Ziganshin.

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Ziganshin, M.A., Gerasimov, A.V., Gorbatchuk, V.V. et al. Thermal analysis of clathrates of tripeptide LLL with organic compounds and water. J Therm Anal Calorim 119, 1811–1816 (2015). https://doi.org/10.1007/s10973-014-4279-0

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  • DOI: https://doi.org/10.1007/s10973-014-4279-0

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