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Bioglass® and resulting crystalline materials synthesized via an acetic acid-assisted sol–gel route

  • Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications
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Abstract

In this study, we report on the synthesis of a bioactive glass powder with the original 45S5 composition (Bioglass®) by means of an acetic acid-assisted sol–gel route. A glassy material was obtained after the gels underwent a thermal stabilization treatment at 600 °C for 3 h. Above this temperature, the heat-treated gels crystallized partially, forming a sodium-calcium-silicate Na2CaSi2O6 phase. Even after crystallization, this material showed in vitro bioactivity in simulated body fluid after 12 h, when the formation of hydroxycarbonate apatite on the material surface was identified by X-ray diffraction. Not surprisingly, microbiological assays revealed that these gel-derived materials appear to have an antibacterial effect against Pseudomonas aeruginosa (ATCC 27853)—a Gram-negative bacterium that is noted for its environmental survival versatility, ability to produce biofilm and resistance to some antibiotics. Thus, using common precursors that are widely available, relatively cheap, simple to use, and which result in gels with low stabilization temperature, it was possible to explore the versatility of sol–gel processing to obtain the golden standard 45S5 bioglass.

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Acknowledgements

We are grateful to the following Brazilian research funding agencies: FAPESP—São Paulo Research Foundation (CEPID—project no. 2013/07793-6) for its generous funding, and CNPq—Conselho Nacional de Desenvolvimento Científico e Tecnológico (Project no. 140516/2013-1) for granting a scholarship to R. L. Siqueira.

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Authors and Affiliations

  1. Laboratório de Materiais Vítreos, Departamento de Engenharia de Materiais, Universidade Federal de São Carlos, Rodovia Washington Luís, Km 235, 13565-905, São Carlos, SP, Brazil

    Renato L. Siqueira, Oscar Peitl & Edgar D. Zanotto

  2. Departamento de Saúde, Universidade Estadual do Sudoeste da Bahia, Campus Jequié, Avenida José Moreira Sobrinho—Jequiezinho, 45205-490, Jequié, BA, Brazil

    Laiza C. Costa

  3. Grupo de Pesquisa em Química de Materiais, Departamento de Ciências Naturais, Universidade Federal de São João del-Rei, Campus Dom Bosco, Praça Dom Helvécio, 74, 36301-160, São João del-Rei, MG, Brazil

    Marco A. Schiavon

  4. Faculdade de Odontologia de Ribeirão Preto, Departamento de Materiais Dentários e Prótese, Universidade de São Paulo, Avenida do Café, s/n°, 14040-904, Ribeirão Preto, SP, Brazil

    Denise T. de Castro & Andréa C. dos Reis

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  1. Renato L. Siqueira
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  2. Laiza C. Costa
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Correspondence to Renato L. Siqueira.

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Siqueira, R.L., Costa, L.C., Schiavon, M.A. et al. Bioglass® and resulting crystalline materials synthesized via an acetic acid-assisted sol–gel route. J Sol-Gel Sci Technol 83, 165–173 (2017). https://doi.org/10.1007/s10971-017-4402-3

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  • DOI: https://doi.org/10.1007/s10971-017-4402-3

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